Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice
Type 2 diabetes (T2D) has emerged as one of the most acute public health diseases of the present time, which increases with the population ageing. This study aimed to evaluate the hypoglycaemic activity of Ulva lactuca oligosaccharide (ULO) under ageing-related diabetes conditions in an animal model...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Food Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927122001034 |
| _version_ | 1811293748586348544 |
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| author | Yihan Chen Weihao Wu Xiaoyu Ni Mohamed A. Farag Esra Capanoglu Chao Zhao |
| author_facet | Yihan Chen Weihao Wu Xiaoyu Ni Mohamed A. Farag Esra Capanoglu Chao Zhao |
| author_sort | Yihan Chen |
| collection | DOAJ |
| description | Type 2 diabetes (T2D) has emerged as one of the most acute public health diseases of the present time, which increases with the population ageing. This study aimed to evaluate the hypoglycaemic activity of Ulva lactuca oligosaccharide (ULO) under ageing-related diabetes conditions in an animal model. The results demonstrated that ULO can promote hypoglycaemia and delay senescence as mediated via GLP-1/GLP-1R pathway to mobilize the intercommunication between the brain and gut. In addition, twenty-six different metabolites and eight different bacteria were screened in the brain and the gut, respectively. A network relationship displayed that all-trans-retinoic acid has positive relationships with Bifidobacterium and Streptococcus, suggesting that plays a potential key role in maintaining the hypoglycaemic and anti-ageing activities of ULO. Based on these findings, ULO might be an efficient therapy for restoring blood glucose metabolism and delaying brain senescence in elderly T2D patients. |
| first_indexed | 2024-04-13T05:07:11Z |
| format | Article |
| id | doaj.art-2c08182e4f6049b88e05c5b9475fb585 |
| institution | Directory Open Access Journal |
| issn | 2665-9271 |
| language | English |
| last_indexed | 2024-04-13T05:07:11Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj.art-2c08182e4f6049b88e05c5b9475fb5852022-12-22T03:01:09ZengElsevierCurrent Research in Food Science2665-92712022-01-01511271139Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic miceYihan Chen0Weihao Wu1Xiaoyu Ni2Mohamed A. Farag3Esra Capanoglu4Chao Zhao5College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, ChinaPharmacognosy Department, College of Pharmacy, Cairo University, Cairo, EgyptDepartment of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, 34469, Istanbul, TurkeyCollege of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, 350002, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Corresponding author. No.15 Shangxiadian Road, Fuzhou, 350002, China.Type 2 diabetes (T2D) has emerged as one of the most acute public health diseases of the present time, which increases with the population ageing. This study aimed to evaluate the hypoglycaemic activity of Ulva lactuca oligosaccharide (ULO) under ageing-related diabetes conditions in an animal model. The results demonstrated that ULO can promote hypoglycaemia and delay senescence as mediated via GLP-1/GLP-1R pathway to mobilize the intercommunication between the brain and gut. In addition, twenty-six different metabolites and eight different bacteria were screened in the brain and the gut, respectively. A network relationship displayed that all-trans-retinoic acid has positive relationships with Bifidobacterium and Streptococcus, suggesting that plays a potential key role in maintaining the hypoglycaemic and anti-ageing activities of ULO. Based on these findings, ULO might be an efficient therapy for restoring blood glucose metabolism and delaying brain senescence in elderly T2D patients.http://www.sciencedirect.com/science/article/pii/S2665927122001034Type 2 diabetesUlva lactuca oligosaccharideSenescenceDifferential metaboliteGut microbiota |
| spellingShingle | Yihan Chen Weihao Wu Xiaoyu Ni Mohamed A. Farag Esra Capanoglu Chao Zhao Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice Current Research in Food Science Type 2 diabetes Ulva lactuca oligosaccharide Senescence Differential metabolite Gut microbiota |
| title | Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice |
| title_full | Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice |
| title_fullStr | Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice |
| title_full_unstemmed | Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice |
| title_short | Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice |
| title_sort | regulatory mechanisms of the green alga ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice |
| topic | Type 2 diabetes Ulva lactuca oligosaccharide Senescence Differential metabolite Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2665927122001034 |
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