Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination
The goal of this paper is to assess the concordance between the clinical diagnosis of Endometrial Hyperplasia (EH), suspected by senior gynecologists throughout outpatient office hysteroscopy, and the results from histopathological examination, in order to evaluate hysteroscopic accuracy for EH. A p...
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MDPI AG
2019-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/9/4/142 |
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| author | Pasquale De Franciscis Gaetano Riemma Antonio Schiattarella Luigi Cobellis Maria Guadagno Salvatore Giovanni Vitale Lavinia Mosca Antonio Cianci Nicola Colacurci |
| author_facet | Pasquale De Franciscis Gaetano Riemma Antonio Schiattarella Luigi Cobellis Maria Guadagno Salvatore Giovanni Vitale Lavinia Mosca Antonio Cianci Nicola Colacurci |
| author_sort | Pasquale De Franciscis |
| collection | DOAJ |
| description | The goal of this paper is to assess the concordance between the clinical diagnosis of Endometrial Hyperplasia (EH), suspected by senior gynecologists throughout outpatient office hysteroscopy, and the results from histopathological examination, in order to evaluate hysteroscopic accuracy for EH. A prospective cohort study was done at a Tertiary University Hospital. From January to December 2018, we enrolled women with the following criteria: abnormal uterine bleeding in post-menopause and endometrial thickening in pre-or post-menopause. Patients underwent office hysteroscopy with a 5 mm continuous-flow hysteroscope, and endometrial biopsies were taken using miniaturized instruments. Senior operators had to foresee histopathological diagnosis using a questionnaire. Histopathological examination was conducted to confirm the diagnosis. This study was approved by the local ethical and registered in the ClinicalTrials.gov registry (ID no. NCT03917147). In 424 cases, 283 clinical diagnoses of EH were determined by senior surgeons. A histopathological diagnosis was then confirmed in 165 cases (58.3%; <i>p</i> = 0.0001). Furthermore, 14 endometrial carcinoma and atypical hyperplasia were found. The sensitivity, positive predictive value, and negative predictive values for EH were, respectively, 90.4, 58.4, and 86.6%. Subdivided by clinical indication, the sensitivity was higher in patients with post-menopause endometrial thickening. The diagnostic accuracy of office hysteroscopy in the diagnosis and prediction of endometrial hyperplasia was high. Senior operators could foresee EHs in more than half the cases. |
| first_indexed | 2024-04-14T00:55:15Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-14T00:55:15Z |
| publishDate | 2019-10-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2c08709e8e1346358db4d17bcf3e6ed82022-12-22T02:21:37ZengMDPI AGDiagnostics2075-44182019-10-019414210.3390/diagnostics9040142diagnostics9040142Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological ExaminationPasquale De Franciscis0Gaetano Riemma1Antonio Schiattarella2Luigi Cobellis3Maria Guadagno4Salvatore Giovanni Vitale5Lavinia Mosca6Antonio Cianci7Nicola Colacurci8Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyUnit of Obstetrics & Gynecology, Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyUnit of Obstetrics & Gynecology, Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyThe goal of this paper is to assess the concordance between the clinical diagnosis of Endometrial Hyperplasia (EH), suspected by senior gynecologists throughout outpatient office hysteroscopy, and the results from histopathological examination, in order to evaluate hysteroscopic accuracy for EH. A prospective cohort study was done at a Tertiary University Hospital. From January to December 2018, we enrolled women with the following criteria: abnormal uterine bleeding in post-menopause and endometrial thickening in pre-or post-menopause. Patients underwent office hysteroscopy with a 5 mm continuous-flow hysteroscope, and endometrial biopsies were taken using miniaturized instruments. Senior operators had to foresee histopathological diagnosis using a questionnaire. Histopathological examination was conducted to confirm the diagnosis. This study was approved by the local ethical and registered in the ClinicalTrials.gov registry (ID no. NCT03917147). In 424 cases, 283 clinical diagnoses of EH were determined by senior surgeons. A histopathological diagnosis was then confirmed in 165 cases (58.3%; <i>p</i> = 0.0001). Furthermore, 14 endometrial carcinoma and atypical hyperplasia were found. The sensitivity, positive predictive value, and negative predictive values for EH were, respectively, 90.4, 58.4, and 86.6%. Subdivided by clinical indication, the sensitivity was higher in patients with post-menopause endometrial thickening. The diagnostic accuracy of office hysteroscopy in the diagnosis and prediction of endometrial hyperplasia was high. Senior operators could foresee EHs in more than half the cases.https://www.mdpi.com/2075-4418/9/4/142endometrial hyperplasiahysteroscopypostmenopauseendometrial cancer |
| spellingShingle | Pasquale De Franciscis Gaetano Riemma Antonio Schiattarella Luigi Cobellis Maria Guadagno Salvatore Giovanni Vitale Lavinia Mosca Antonio Cianci Nicola Colacurci Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination Diagnostics endometrial hyperplasia hysteroscopy postmenopause endometrial cancer |
| title | Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination |
| title_full | Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination |
| title_fullStr | Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination |
| title_full_unstemmed | Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination |
| title_short | Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination |
| title_sort | concordance between the hysteroscopic diagnosis of endometrial hyperplasia and histopathological examination |
| topic | endometrial hyperplasia hysteroscopy postmenopause endometrial cancer |
| url | https://www.mdpi.com/2075-4418/9/4/142 |
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