Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques.
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20141-z |
| _version_ | 1818851187223429120 |
|---|---|
| author | Jeroen Baardman Sanne G. S. Verberk Saskia van der Velden Marion J. J. Gijbels Cindy P. P. A. van Roomen Judith C. Sluimer Jelle Y. Broos Guillermo R. Griffith Koen H. M. Prange Michel van Weeghel Soufyan Lakbir Douwe Molenaar Elisa Meinster Annette E. Neele Gijs Kooij Helga E. de Vries Esther Lutgens Kathryn E. Wellen Menno P. J. de Winther Jan Van den Bossche |
| author_facet | Jeroen Baardman Sanne G. S. Verberk Saskia van der Velden Marion J. J. Gijbels Cindy P. P. A. van Roomen Judith C. Sluimer Jelle Y. Broos Guillermo R. Griffith Koen H. M. Prange Michel van Weeghel Soufyan Lakbir Douwe Molenaar Elisa Meinster Annette E. Neele Gijs Kooij Helga E. de Vries Esther Lutgens Kathryn E. Wellen Menno P. J. de Winther Jan Van den Bossche |
| author_sort | Jeroen Baardman |
| collection | DOAJ |
| description | Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques. |
| first_indexed | 2024-12-19T07:01:02Z |
| format | Article |
| id | doaj.art-2c0a011d044046398f11e576a0b58fa9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T07:01:02Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2c0a011d044046398f11e576a0b58fa92022-12-21T20:31:24ZengNature PortfolioNature Communications2041-17232020-12-0111111510.1038/s41467-020-20141-zMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaquesJeroen Baardman0Sanne G. S. Verberk1Saskia van der Velden2Marion J. J. Gijbels3Cindy P. P. A. van Roomen4Judith C. Sluimer5Jelle Y. Broos6Guillermo R. Griffith7Koen H. M. Prange8Michel van Weeghel9Soufyan Lakbir10Douwe Molenaar11Elisa Meinster12Annette E. Neele13Gijs Kooij14Helga E. de Vries15Esther Lutgens16Kathryn E. Wellen17Menno P. J. de Winther18Jan Van den Bossche19Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamDepartment of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamDepartment of Pathology and Molecular Genetics, CARIM, Maastricht UniversityDepartment of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamLaboratory Genetic Metabolic Diseases, Amsterdam Cardiovascular sciences, Amsterdam UMC, University of AmsterdamDepartment of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamSystems Bioinformatics, Vrije Universiteit AmsterdamDepartment of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamDepartment of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of PennsylvaniaDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Infection and Immunity, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of AmsterdamInhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques.https://doi.org/10.1038/s41467-020-20141-z |
| spellingShingle | Jeroen Baardman Sanne G. S. Verberk Saskia van der Velden Marion J. J. Gijbels Cindy P. P. A. van Roomen Judith C. Sluimer Jelle Y. Broos Guillermo R. Griffith Koen H. M. Prange Michel van Weeghel Soufyan Lakbir Douwe Molenaar Elisa Meinster Annette E. Neele Gijs Kooij Helga E. de Vries Esther Lutgens Kathryn E. Wellen Menno P. J. de Winther Jan Van den Bossche Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques Nature Communications |
| title | Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_full | Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_fullStr | Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_full_unstemmed | Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_short | Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_sort | macrophage atp citrate lyase deficiency stabilizes atherosclerotic plaques |
| url | https://doi.org/10.1038/s41467-020-20141-z |
| work_keys_str_mv | AT jeroenbaardman macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT sannegsverberk macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT saskiavandervelden macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT marionjjgijbels macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT cindyppavanroomen macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT judithcsluimer macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT jelleybroos macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT guillermorgriffith macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT koenhmprange macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT michelvanweeghel macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT soufyanlakbir macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT douwemolenaar macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT elisameinster macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT annetteeneele macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT gijskooij macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT helgaedevries macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT estherlutgens macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT kathrynewellen macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT mennopjdewinther macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT janvandenbossche macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques |