A Cascade Signal Amplification Strategy for the Ultrasensitive Fluorescence Detection of Cu<sup>2+</sup> via λ-Exonuclease-Assisted Target Recycling with Mismatched Catalytic Hairpin Assembly

A Cascade Signal Amplification Strategy for the Ultrasensitive Fluorescence Detection of Cu<sup>2+</sup> via λ-Exonuclease-Assisted Target Recycling with Mismatched Catalytic Hairpin Assembly

Herein, an ultrasensitive DNAzyme-based fluorescence biosensor for detecting Cu<sup>2+</sup> was designed using the cascade signal amplification strategy, coupling λ-exonuclease-assisted target recycling and mismatched catalytic hairpin assembly (MCHA). In the designed detection system,...

Full description

Bibliographic Details
Main Authors:	Zhen Liu, Chen Liu, Liqiong He, Jinquan Liu, Le Li, Shengyuan Yang, Yan Tan, Xing Liu, Xilin Xiao
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	Biosensors
Subjects:	Cu<sup>2+</sup> detection λ-exonuclease-assisted target recycling mismatched catalytic hairpin assembly cascade signal amplification environmental pollutant
Online Access:	https://www.mdpi.com/2079-6374/13/10/918

Similar Items

Function of Graphene Oxide as the “Nanoquencher” for Hg<sup>2+</sup> Detection Using an Exonuclease I-Assisted Biosensor
by: Ting Sun, et al.
Published: (2022-06-01)

A Fluorescent Biosensor for Streptavidin Detection Based on Double-Hairpin DNA-Templated Copper Nanoparticles
by: Qiangsheng Xiao, et al.
Published: (2023-01-01)

A Novel Colorimetric Nano Aptasensor for Ultrasensitive Detection of Aflatoxin B1 Based on the Exonuclease III-Assisted Signal Amplification Approach
by: Yu Chen, et al.
Published: (2021-10-01)

Approximation of Fractional Order PI<sup>λ</sup>D<sup>μ</sup>-Controller Transfer Function Using Chain Fractions
by: Yaroslav Marushchak, et al.
Published: (2022-07-01)

Exonuclease III Can Efficiently Cleave Linear Single-Stranded DNA: Reshaping Its Experimental Applications in Biosensors
by: Yi Shen, et al.
Published: (2023-05-01)

Rapid Detection of Malaria Based on Hairpin-Mediated Amplification and Lateral Flow Detection
by: Yang Zhang, et al.
Published: (2023-10-01)

Dual-Loop Voltage–Current Control of a Fractional-Order Buck-Boost Converter Using a Fractional-Order PI<sup>λ</sup> Controller
by: Lingling Xie, et al.
Published: (2023-03-01)

New Method of Isothermal, Hairpin Assisted, Primer Independent Amplification of DNA
by: Denis Sergeevich Naberezhnov, et al.
Published: (2023-09-01)

Fractional-Order PI<sup>λ</sup>D<sup>μ</sup> Controller Using Adaptive Neural Fuzzy Model for Course Control of Underactuated Ships
by: Guangyu Li, et al.
Published: (2022-05-01)

The Reactions of Alkenes with Phenyl-<i>N</i>-triflylimino-λ<sup>3</sup>-iodane: Solvent and Oxidant Impact
by: Mikhail Yu. Moskalik, et al.
Published: (2023-11-01)

Quantitation of MicroRNA-155 in Human Cells by Heterogeneous Enzyme-Linked Oligonucleotide Assay Coupled with Mismatched Catalytic Hairpin Assembly Reaction
by: Oleg L. Bodulev, et al.
Published: (2022-07-01)

Fractional PI<sup><i>λ</i></sup>D Controller Design for a Magnetic Levitation System
by: Waldemar Bauer, et al.
Published: (2020-12-01)

CRISPR/Cas12a Collateral Cleavage Activity for Sensitive 3′–5′ Exonuclease Assay
by: Jae Hoon Jeung, et al.
Published: (2023-10-01)

Parameter–Elliptic Fourier Multipliers Systems and Generation of Analytic and <i>C</i><sup>∞</sup> Semigroups
by: Bienvenido Barraza Martínez, et al.
Published: (2022-02-01)

Mismatch Repair Protein Msh6<sup>Tt</sup> Is Necessary for Nuclear Division and Gametogenesis in <i>Tetrahymena thermophila</i>
by: Lin Wang, et al.
Published: (2023-12-01)

Glutamate-Evoked Ca<sup>2+</sup> Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na<sup>+</sup>/K<sup>+</sup>-ATPase and Na<sup>+</sup>/Ca<sup>2+</sup>-Exchanger
by: Pi-Cheng Cheng, et al.
Published: (2023-03-01)

An Encryption Algorithm for Region of Interest in Medical DICOM Based on One-Dimensional <i>e<sup>λ</sup></i>-cos-cot Map
by: Xin Meng, et al.
Published: (2022-06-01)

Heterotridentate Organomonophosphines in Pt(κ<sup>3</sup>–X<sup>1</sup>P<sup>1</sup>X<sup>2</sup>)(Y) (X<sup>1,2</sup> = N<sup>1,2</sup> or S<sup>1,2</sup>), Pt(κ<sup>3</sup>–P<sup>1</sup>N<sup>1</sup>X<sup>1</sup>)(Y) (X<sup>1</sup> = O, C, S or Se) Pt(κ<sup>3</sup>–P<sup>1</sup>S<sup>1</sup>Cl<sup>1</sup>)(Cl) and Pt(κ<sup>3</sup>–P<sup>1</sup>Si<sup>1</sup>N<sup>1</sup>)(OL)—Structural Aspects
by: Milan Melník, et al.
Published: (2022-12-01)

Na<sup>+</sup>,K<sup>+</sup>-ATPase with Disrupted Na<sup>+</sup> Binding Sites I and III Binds Na<sup>+</sup> with Increased Affinity at Site II and Undergoes Na<sup>+</sup>-Activated Phosphorylation with ATP
by: Hang N. Nielsen, et al.
Published: (2024-01-01)

A Multifunctional Fluorescent Probe Based on 1,8-Naphthalimide for the Detection of Co<sup>2+</sup>, F<sup>−</sup>, and CN<sup>−</sup>
by: Ping Li, et al.
Published: (2023-06-01)

Spinach Plants Favor the Absorption of K<sup>+</sup> over Na<sup>+</sup> Regardless of Salinity, and May Benefit from Na<sup>+</sup> When K<sup>+</sup> is Deficient in the Soil
by: Jorge F. S. Ferreira, et al.
Published: (2020-04-01)

Comparative Na<sup>+</sup> and K<sup>+</sup> Profiling Reveals Microbial Community Assembly of Alfalfa Silage in Different Saline-Alkali Soils
by: Shengnan Li, et al.
Published: (2023-09-01)

Organomonophosphines in Pt(η<sup>3</sup>-X<sup>1</sup>X<sup>2</sup>X<sup>3</sup>)(PR<sub>3</sub>), (X = N<sup>1</sup>, N<sup>2</sup>, N<sup>3</sup>; S<sup>1</sup>, S<sup>2</sup>, S<sup>3</sup>; or Te<sup>1</sup>, Te<sup>2</sup>, Te<sup>3</sup>) Derivatives: Structural Aspects
by: Milan Melník, et al.
Published: (2023-06-01)

The Pseudo-Protic Ionic Liquids TOAH<sup>+</sup>Cl<sup>−</sup> and TODAH<sup>+</sup>Cl<sup>−</sup> as Carriers for Facilitated Transport of In(III) from HCl Solutions
by: Francisco José Alguacil, et al.
Published: (2022-12-01)

Removal of Fe<sup>2+</sup> and Mn<sup>2+</sup> from Polluted Groundwater by Insoluble Humic Acid/Tourmaline Composite Particles
by: Ling Liu, et al.
Published: (2022-04-01)

Effects of Oregano Essential Oil on IgA<sup>+</sup>, IgG<sup>+</sup>, and IgM<sup>+</sup> Cells in the Jejunum of Castrated Holstein Bulls
by: Qiyan Liu, et al.
Published: (2023-12-01)

Ontogenetic Development of Gill and Na<sup>+</sup>/K<sup>+</sup> ATPase in the Air-Breathing Loach
by: Yaqiu Liu, et al.
Published: (2022-12-01)

Suppressing Effect of Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells
by: Zikai Liu, et al.
Published: (2022-01-01)

Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose<sup>®</sup> 80, CombiLac<sup>®</sup>, MicroceLac<sup>®</sup> 100, and StarLac<sup>®</sup>
by: Martin Dominik, et al.
Published: (2021-09-01)

Hydrochemical and Isotope (<sup>18</sup>O, <sup>2</sup>H and <sup>3</sup>H) Characteristics of Karst Water in Central Shandong Province: A Case Study of the Pingyi-Feixian Region
by: Chunhua Liu, et al.
Published: (2022-01-01)

TLTC, a T5 exonuclease–mediated low-temperature DNA cloning method
by: Fang Yu, et al.
Published: (2023-08-01)

K<sup>+</sup> and Ca<sup>2+</sup> Channels Regulate Ca<sup>2+</sup> Signaling in Chondrocytes: An Illustrated Review
by: Yoshiaki Suzuki, et al.
Published: (2020-06-01)

High Removal Efficiency of Diatomite-Based X Zeolite for Cu<sup>2+</sup> and Zn<sup>2+</sup>
by: Guangyuan Yao, et al.
Published: (2021-10-01)

Safranal Induces Vasorelaxation by Inhibiting Ca<sup>2+</sup> Influx and Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Isolated Rat Aortic Rings
by: Noor Nadhim Al-Saigh, et al.
Published: (2022-06-01)

Rare Earth Elements Geochemistry and <sup>234</sup>U/<sup>238</sup>U, <sup>235</sup>U/<sup>238</sup>U Isotope Ratios of the Kanyakumari Beach Placer Deposits: Occurrence and Provenance
by: Thennaarassan Natarajan, et al.
Published: (2023-06-01)

Midazolam’s Effects on Delayed-Rectifier K<sup>+</sup> Current and Intermediate-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel in Jurkat T-lymphocytes
by: Ning-Ping Foo, et al.
Published: (2021-07-01)

<sup>40</sup>Ar/<sup>39</sup>Ar Ages and Geochemistry of Seamount Basalts from the Western Pacific Province
by: Qian Liu, et al.
Published: (2022-01-01)

Mitochondrial DNA tRNA<sup>Leu</sup> and tRNA<sup>Ser</sup> polymorphism in different pig breeds
by: M. A. Kolosova, et al.
Published: (2018-10-01)

Chemical Separation of Uranium and Precise Measurement of <sup>234</sup>U/<sup>238</sup>U and <sup>235</sup>U/<sup>238</sup>U Ratios in Soil Samples Using Multi Collector Inductively Coupled Plasma Mass Spectrometry
by: Nimelan Veerasamy, et al.
Published: (2020-05-01)

Meteoric <sup>10</sup>Be, <sup>137</sup>Cs and <sup>239+240</sup>Pu as Tracers of Long- and Medium-Term Soil Erosion—A Review
by: Aleksandra Loba, et al.
Published: (2022-03-01)