Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications
Editorial summary Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities hav...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | Genome Medicine |
| Online Access: | http://link.springer.com/article/10.1186/s13073-017-0460-y |
| _version_ | 1811283190857334784 |
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| author | Masayuki Fujii Toshiro Sato |
| author_facet | Masayuki Fujii Toshiro Sato |
| author_sort | Masayuki Fujii |
| collection | DOAJ |
| description | Editorial summary Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5+ intestinal stem cells, providing insights into their roles in homeostasis and cancer. |
| first_indexed | 2024-04-13T02:07:02Z |
| format | Article |
| id | doaj.art-2c0cb119fd784ad3b6e40da20373285c |
| institution | Directory Open Access Journal |
| issn | 1756-994X |
| language | English |
| last_indexed | 2024-04-13T02:07:02Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Medicine |
| spelling | doaj.art-2c0cb119fd784ad3b6e40da20373285c2022-12-22T03:07:26ZengBMCGenome Medicine1756-994X2017-07-01911410.1186/s13073-017-0460-yDefining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applicationsMasayuki Fujii0Toshiro Sato1Department of Gastroenterology, Keio University School of MedicineDepartment of Gastroenterology, Keio University School of MedicineEditorial summary Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5+ intestinal stem cells, providing insights into their roles in homeostasis and cancer.http://link.springer.com/article/10.1186/s13073-017-0460-y |
| spellingShingle | Masayuki Fujii Toshiro Sato Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications Genome Medicine |
| title | Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications |
| title_full | Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications |
| title_fullStr | Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications |
| title_full_unstemmed | Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications |
| title_short | Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications |
| title_sort | defining the role of lgr5 stem cells in colorectal cancer from basic research to clinical applications |
| url | http://link.springer.com/article/10.1186/s13073-017-0460-y |
| work_keys_str_mv | AT masayukifujii definingtheroleoflgr5stemcellsincolorectalcancerfrombasicresearchtoclinicalapplications AT toshirosato definingtheroleoflgr5stemcellsincolorectalcancerfrombasicresearchtoclinicalapplications |