A practical nomogram based on serum interleukin-6 for the prognosis of liver failure
BackgroundLiver failure (LF) is a serious liver function damage caused by various factors, mainly jaundice, hepatic encephalopathy, coagulation disorders and multiple organ failure, with the clinical characteristic of high short-term mortality. LF is often accompanied by excessive activation of infl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1035699/full |
| _version_ | 1797988539012481024 |
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| author | Nanxi Xiao Linxiang Liu Yue Zhang Yuan Nie Xuan Zhu |
| author_facet | Nanxi Xiao Linxiang Liu Yue Zhang Yuan Nie Xuan Zhu |
| author_sort | Nanxi Xiao |
| collection | DOAJ |
| description | BackgroundLiver failure (LF) is a serious liver function damage caused by various factors, mainly jaundice, hepatic encephalopathy, coagulation disorders and multiple organ failure, with the clinical characteristic of high short-term mortality. LF is often accompanied by excessive activation of inflammatory factors, and an excessive systemic inflammatory response (i.e., inflammatory storm) is considered to be the trigger of LF. However, a specific prognostic model including inflammatory factors for patients with LF has not been well established.AimTo establish and validate a nomogram for predicting 28-day, 90-day, and 180-day mortality in patients with LF.MethodsA total of 423 eligible LF patients were enrolled in this retrospective study. Independent predictors were identified using a multivariate logistic model and then integrated into a nomogram to predict 28-day, 90-day, and 180-day mortality. The concordance index, receiver operating characteristic curves, and calibration plots were used to evaluate the performance of the model.ResultsSex, age, total bilirubin, aspartate aminotransferase, international normalized ratio, Child–Pugh score, and serum interleukin-6 were independent risk factors for death at 28, 90, and 180 days in LF patients. The nomogram showed good calibration and discrimination with an area under the receiver operating characteristic curve (AUC) of 0.927. The calibration curve fit as well, indicating that the nomogram had good clinical application value.ConclusionThis nomogram model for predicting the 28-day, 90-day, and 180-day mortality of LF patients could help optimize treatment strategies and improve prognosis. |
| first_indexed | 2024-04-11T08:05:38Z |
| format | Article |
| id | doaj.art-2c1142f731594e988bd1b6b99a7c20ec |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T08:05:38Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-2c1142f731594e988bd1b6b99a7c20ec2022-12-22T04:35:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.10356991035699A practical nomogram based on serum interleukin-6 for the prognosis of liver failureNanxi XiaoLinxiang LiuYue ZhangYuan NieXuan ZhuBackgroundLiver failure (LF) is a serious liver function damage caused by various factors, mainly jaundice, hepatic encephalopathy, coagulation disorders and multiple organ failure, with the clinical characteristic of high short-term mortality. LF is often accompanied by excessive activation of inflammatory factors, and an excessive systemic inflammatory response (i.e., inflammatory storm) is considered to be the trigger of LF. However, a specific prognostic model including inflammatory factors for patients with LF has not been well established.AimTo establish and validate a nomogram for predicting 28-day, 90-day, and 180-day mortality in patients with LF.MethodsA total of 423 eligible LF patients were enrolled in this retrospective study. Independent predictors were identified using a multivariate logistic model and then integrated into a nomogram to predict 28-day, 90-day, and 180-day mortality. The concordance index, receiver operating characteristic curves, and calibration plots were used to evaluate the performance of the model.ResultsSex, age, total bilirubin, aspartate aminotransferase, international normalized ratio, Child–Pugh score, and serum interleukin-6 were independent risk factors for death at 28, 90, and 180 days in LF patients. The nomogram showed good calibration and discrimination with an area under the receiver operating characteristic curve (AUC) of 0.927. The calibration curve fit as well, indicating that the nomogram had good clinical application value.ConclusionThis nomogram model for predicting the 28-day, 90-day, and 180-day mortality of LF patients could help optimize treatment strategies and improve prognosis.https://www.frontiersin.org/articles/10.3389/fmed.2022.1035699/fullliver failureinflammatory factorsdiagnosisprognosissystemic inflammation |
| spellingShingle | Nanxi Xiao Linxiang Liu Yue Zhang Yuan Nie Xuan Zhu A practical nomogram based on serum interleukin-6 for the prognosis of liver failure Frontiers in Medicine liver failure inflammatory factors diagnosis prognosis systemic inflammation |
| title | A practical nomogram based on serum interleukin-6 for the prognosis of liver failure |
| title_full | A practical nomogram based on serum interleukin-6 for the prognosis of liver failure |
| title_fullStr | A practical nomogram based on serum interleukin-6 for the prognosis of liver failure |
| title_full_unstemmed | A practical nomogram based on serum interleukin-6 for the prognosis of liver failure |
| title_short | A practical nomogram based on serum interleukin-6 for the prognosis of liver failure |
| title_sort | practical nomogram based on serum interleukin 6 for the prognosis of liver failure |
| topic | liver failure inflammatory factors diagnosis prognosis systemic inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1035699/full |
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