Contribution of cryptic epitopes in designing a group A streptococcal vaccine
A successful vaccine needs to target multiple strains of an organism. Streptococcus pyogenes is an organism that utilizes antigenic strain variation as a successful defence mechanism to circumvent the host immune response. Despite numerous efforts, there is currently no vaccine available for this or...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-08-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1462427 |
| _version_ | 1797677460452540416 |
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| author | Victoria Ozberk Manisha Pandey Michael F. Good |
| author_facet | Victoria Ozberk Manisha Pandey Michael F. Good |
| author_sort | Victoria Ozberk |
| collection | DOAJ |
| description | A successful vaccine needs to target multiple strains of an organism. Streptococcus pyogenes is an organism that utilizes antigenic strain variation as a successful defence mechanism to circumvent the host immune response. Despite numerous efforts, there is currently no vaccine available for this organism. Here we review and discuss the significant obstacles to vaccine development, with a focus on how cryptic epitopes may provide a strategy to circumvent the obstacles of antigenic variation. |
| first_indexed | 2024-03-11T22:45:29Z |
| format | Article |
| id | doaj.art-2c1147e611a945a9900a9cd28da9a17b |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:45:29Z |
| publishDate | 2018-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-2c1147e611a945a9900a9cd28da9a17b2023-09-22T08:38:21ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-08-011482034205210.1080/21645515.2018.14624271462427Contribution of cryptic epitopes in designing a group A streptococcal vaccineVictoria Ozberk0Manisha Pandey1Michael F. Good2Griffith University, Institute for GlycomicsGriffith University, Institute for GlycomicsGriffith University, Institute for GlycomicsA successful vaccine needs to target multiple strains of an organism. Streptococcus pyogenes is an organism that utilizes antigenic strain variation as a successful defence mechanism to circumvent the host immune response. Despite numerous efforts, there is currently no vaccine available for this organism. Here we review and discuss the significant obstacles to vaccine development, with a focus on how cryptic epitopes may provide a strategy to circumvent the obstacles of antigenic variation.http://dx.doi.org/10.1080/21645515.2018.1462427streptococcus pyogenesgroup a streptococcus (gas)cryptic epitopesvaccinej8-dtj14spyceps2skin infectionbacteraemialiposomesurt (upper respiratory tract)intranasal |
| spellingShingle | Victoria Ozberk Manisha Pandey Michael F. Good Contribution of cryptic epitopes in designing a group A streptococcal vaccine Human Vaccines & Immunotherapeutics streptococcus pyogenes group a streptococcus (gas) cryptic epitopes vaccine j8-dt j14 spycep s2 skin infection bacteraemia liposomes urt (upper respiratory tract) intranasal |
| title | Contribution of cryptic epitopes in designing a group A streptococcal vaccine |
| title_full | Contribution of cryptic epitopes in designing a group A streptococcal vaccine |
| title_fullStr | Contribution of cryptic epitopes in designing a group A streptococcal vaccine |
| title_full_unstemmed | Contribution of cryptic epitopes in designing a group A streptococcal vaccine |
| title_short | Contribution of cryptic epitopes in designing a group A streptococcal vaccine |
| title_sort | contribution of cryptic epitopes in designing a group a streptococcal vaccine |
| topic | streptococcus pyogenes group a streptococcus (gas) cryptic epitopes vaccine j8-dt j14 spycep s2 skin infection bacteraemia liposomes urt (upper respiratory tract) intranasal |
| url | http://dx.doi.org/10.1080/21645515.2018.1462427 |
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