Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors

Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors

Modern microscopy has revealed that core nuclear functions, including transcription, replication, and heterochromatin formation, occur in spatially restricted clusters. Previous work from our lab has shown that subnuclear high-concentration clusters of transcription factors may play a role in regula...

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Bibliographic Details
Main Authors: Colleen E Hannon, Michael B Eisen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
transcription factors
confocal microscopy
protein disorder
protein structure prediction
Online Access:https://elifesciences.org/articles/88221

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