Molecular mechanism of α-Hederin in tumor progression
α-Hederin is a monosaccharide pentacyclic triterpene saponin compound derived from the Chinese herb, Pulsatilla. It has garnered considerable attention for its anti-tumor, anti-inflammatory, and spasmolytic pharmacological activities. Given the rising incidence of cancer and the pronounced adverse r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223018954 |
| _version_ | 1797364211864567808 |
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| author | Dandan Meng Meng Ren Maofeng Li Min Wang Wei Geng Qingxin Shang |
| author_facet | Dandan Meng Meng Ren Maofeng Li Min Wang Wei Geng Qingxin Shang |
| author_sort | Dandan Meng |
| collection | DOAJ |
| description | α-Hederin is a monosaccharide pentacyclic triterpene saponin compound derived from the Chinese herb, Pulsatilla. It has garnered considerable attention for its anti-tumor, anti-inflammatory, and spasmolytic pharmacological activities. Given the rising incidence of cancer and the pronounced adverse reactions associated with chemotherapy drugs—which profoundly impact the quality of life for cancer patients—there is an immediate need for safe and effective antitumor agents. Traditional drugs and their anticancer effects have become a focal point of research in recent years. Studies indicate that α-Hederin can hinder tumor cell proliferation and impede the advancement of various cancers, including breast, lung, colorectal, and liver cancers. The principal mechanism behind its anti-tumor activity involves inhibiting tumor cell proliferation, facilitating tumor cell apoptosis, and arresting the cell cycle process. Current evidence suggests that α-Hederin can exert its anti-tumor properties through diverse mechanisms, positioning it as a promising agent in anti-tumor therapy. However, a comprehensive literature search revealed a gap in the comprehensive understanding of α-Hederin. This paper aims to review the available literature on the anti-tumor mechanisms of α-Hederin, hoping to provide valuable insights for the clinical treatment of malignant tumors and the innovation of novel anti-tumor medications. |
| first_indexed | 2024-03-08T16:32:02Z |
| format | Article |
| id | doaj.art-2c1575f4dbe34f459a0569286e76ca6d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:32:02Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-2c1575f4dbe34f459a0569286e76ca6d2024-01-06T04:38:17ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170116097Molecular mechanism of α-Hederin in tumor progressionDandan Meng0Meng Ren1Maofeng Li2Min Wang3Wei Geng4Qingxin Shang5Department of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, No. 4655, Daxue Road, Changqing District, Jinan 250355, Shangdong, ChinaDepartment of Physical Education, Shandong University of Traditional Chinese Medicine, No. 4655, Daxue Road, Changqing District, Jinan 250355, Shangdong, ChinaCollege of Foreign Chinese, Shandong University of Traditional Chinese Medicine, No. 4655, Daxue Road, Changqing District, Jinan 250355, Shangdong, ChinaExperimental Center of Shandong University of Traditional Chinese Medicine, No. 4655, Daxue Road, Changqing District, Jinan 250355, Shangdong, ChinaShandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, No. 238, Jingshi East Road, Lixia District, Jinan 250014, ChinaDepartment of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, No. 4655, Daxue Road, Changqing District, Jinan 250355, Shangdong, China; Corresponding author.α-Hederin is a monosaccharide pentacyclic triterpene saponin compound derived from the Chinese herb, Pulsatilla. It has garnered considerable attention for its anti-tumor, anti-inflammatory, and spasmolytic pharmacological activities. Given the rising incidence of cancer and the pronounced adverse reactions associated with chemotherapy drugs—which profoundly impact the quality of life for cancer patients—there is an immediate need for safe and effective antitumor agents. Traditional drugs and their anticancer effects have become a focal point of research in recent years. Studies indicate that α-Hederin can hinder tumor cell proliferation and impede the advancement of various cancers, including breast, lung, colorectal, and liver cancers. The principal mechanism behind its anti-tumor activity involves inhibiting tumor cell proliferation, facilitating tumor cell apoptosis, and arresting the cell cycle process. Current evidence suggests that α-Hederin can exert its anti-tumor properties through diverse mechanisms, positioning it as a promising agent in anti-tumor therapy. However, a comprehensive literature search revealed a gap in the comprehensive understanding of α-Hederin. This paper aims to review the available literature on the anti-tumor mechanisms of α-Hederin, hoping to provide valuable insights for the clinical treatment of malignant tumors and the innovation of novel anti-tumor medications.http://www.sciencedirect.com/science/article/pii/S0753332223018954α-HederinAnticancer activityMolecular mechanismsPreclinical experiments |
| spellingShingle | Dandan Meng Meng Ren Maofeng Li Min Wang Wei Geng Qingxin Shang Molecular mechanism of α-Hederin in tumor progression Biomedicine & Pharmacotherapy α-Hederin Anticancer activity Molecular mechanisms Preclinical experiments |
| title | Molecular mechanism of α-Hederin in tumor progression |
| title_full | Molecular mechanism of α-Hederin in tumor progression |
| title_fullStr | Molecular mechanism of α-Hederin in tumor progression |
| title_full_unstemmed | Molecular mechanism of α-Hederin in tumor progression |
| title_short | Molecular mechanism of α-Hederin in tumor progression |
| title_sort | molecular mechanism of α hederin in tumor progression |
| topic | α-Hederin Anticancer activity Molecular mechanisms Preclinical experiments |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223018954 |
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