The complex role of inflammation and gliotransmitters in Parkinson's disease
Our understanding of the role of innate and adaptive immune cell function in brain health and how it goes awry during aging and neurodegenerative diseases is still in its infancy. Inflammation and immunological dysfunction are common components of Parkinson’s disease (PD), both in terms of motor and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996122003321 |
| _version_ | 1797978270796349440 |
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| author | Adithya Gopinath Phillip M. Mackie Leah T. Phan Malú Gámez Tansey Habibeh Khoshbouei |
| author_facet | Adithya Gopinath Phillip M. Mackie Leah T. Phan Malú Gámez Tansey Habibeh Khoshbouei |
| author_sort | Adithya Gopinath |
| collection | DOAJ |
| description | Our understanding of the role of innate and adaptive immune cell function in brain health and how it goes awry during aging and neurodegenerative diseases is still in its infancy. Inflammation and immunological dysfunction are common components of Parkinson’s disease (PD), both in terms of motor and non-motor components of PD. In recent decades, the antiquated notion that the central nervous system (CNS) in disease states is an immune-privileged organ, has been debunked. The immune landscape in the CNS influences peripheral systems, and peripheral immunological changes can alter the CNS in health and disease. Identifying immune and inflammatory pathways that compromise neuronal health and survival is critical in designing innovative and effective strategies to limit their untoward effects on neuronal health. |
| first_indexed | 2024-04-11T05:20:15Z |
| format | Article |
| id | doaj.art-2c157e495e4e4c1999b71316634ba563 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-04-11T05:20:15Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-2c157e495e4e4c1999b71316634ba5632022-12-24T04:50:16ZengElsevierNeurobiology of Disease1095-953X2023-01-01176105940The complex role of inflammation and gliotransmitters in Parkinson's diseaseAdithya Gopinath0Phillip M. Mackie1Leah T. Phan2Malú Gámez Tansey3Habibeh Khoshbouei4Corresponding authors.; Department of Neuroscience, University of Florida, Gainesville, FL, USADepartment of Neuroscience, University of Florida, Gainesville, FL, USADepartment of Neuroscience, University of Florida, Gainesville, FL, USACorresponding authors.; Department of Neuroscience, University of Florida, Gainesville, FL, USACorresponding authors.; Department of Neuroscience, University of Florida, Gainesville, FL, USAOur understanding of the role of innate and adaptive immune cell function in brain health and how it goes awry during aging and neurodegenerative diseases is still in its infancy. Inflammation and immunological dysfunction are common components of Parkinson’s disease (PD), both in terms of motor and non-motor components of PD. In recent decades, the antiquated notion that the central nervous system (CNS) in disease states is an immune-privileged organ, has been debunked. The immune landscape in the CNS influences peripheral systems, and peripheral immunological changes can alter the CNS in health and disease. Identifying immune and inflammatory pathways that compromise neuronal health and survival is critical in designing innovative and effective strategies to limit their untoward effects on neuronal health.http://www.sciencedirect.com/science/article/pii/S0969996122003321Parkinson’s diseaseImmunityCytokinesMicrogliaPeripheral immunityNeuroimmunology |
| spellingShingle | Adithya Gopinath Phillip M. Mackie Leah T. Phan Malú Gámez Tansey Habibeh Khoshbouei The complex role of inflammation and gliotransmitters in Parkinson's disease Neurobiology of Disease Parkinson’s disease Immunity Cytokines Microglia Peripheral immunity Neuroimmunology |
| title | The complex role of inflammation and gliotransmitters in Parkinson's disease |
| title_full | The complex role of inflammation and gliotransmitters in Parkinson's disease |
| title_fullStr | The complex role of inflammation and gliotransmitters in Parkinson's disease |
| title_full_unstemmed | The complex role of inflammation and gliotransmitters in Parkinson's disease |
| title_short | The complex role of inflammation and gliotransmitters in Parkinson's disease |
| title_sort | complex role of inflammation and gliotransmitters in parkinson s disease |
| topic | Parkinson’s disease Immunity Cytokines Microglia Peripheral immunity Neuroimmunology |
| url | http://www.sciencedirect.com/science/article/pii/S0969996122003321 |
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