Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Soluble karyopherins of the importin-β (impβ) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we identify a stable pool of impβ at the NPC. A subpopulation...

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Bibliographic Details
Main Authors: Alan R Lowe, Jeffrey H Tang, Jaime Yassif, Michael Graf, William YC Huang, Jay T Groves, Karsten Weis, Jan T Liphardt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
nuclear pore complex
ran
importin-beta
super-resolution microscopy
Online Access:https://elifesciences.org/articles/04052

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