Skewed Lung CCR4 to CCR6 CD4+ T Cell Ratio in Idiopathic Pulmonary Fibrosis is Associated with Pulmonary Function

Skewed Lung CCR4 to CCR6 CD4+ T Cell Ratio in Idiopathic Pulmonary Fibrosis is Associated with Pulmonary Function

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease. While it has been suggested that T cells may contribute to IPF pathogenesis, these studies have focused primarily on T cells outside of the pulmonary interstitium. Thus, the role of T cells in the diseased lung tiss...

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Bibliographic Details
Main Authors: Ayodeji Adegunsoye, Cara Hrusch, Catherine Bonham, Mohammad R Jaffrey, Kelly M Blaine, Meghan Sullivan, Matthew M Churpek, Mary E Strek, Imre Noth, Anne I Sperling
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Idiopathic Pulmonary Fibrosis
T cells
CD4
Chemokine receptors
Lung function
forced vital capacity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00516/full

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