Diabetic Gastroparesis: Navigating Pathophysiology and Nutritional Interventions
Diabetic gastroparesis (DGP) delays gastric emptying in diabetes patients, notably impacting those with type 1 and long-standing type 2 diabetes. Symptoms include early satiety, fullness, appetite loss, bloating, abdominal pain, and vomiting, arising from slow stomach-to-intestine food movement. DGP...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Gastrointestinal Disorders |
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| Online Access: | https://www.mdpi.com/2624-5647/6/1/16 |
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| author | Alfredo Caturano Massimiliano Cavallo Davide Nilo Gaetano Vaudo Vincenzo Russo Raffaele Galiero Luca Rinaldi Raffaele Marfella Marcellino Monda Giovanni Luca Ferdinando Carlo Sasso |
| author_facet | Alfredo Caturano Massimiliano Cavallo Davide Nilo Gaetano Vaudo Vincenzo Russo Raffaele Galiero Luca Rinaldi Raffaele Marfella Marcellino Monda Giovanni Luca Ferdinando Carlo Sasso |
| author_sort | Alfredo Caturano |
| collection | DOAJ |
| description | Diabetic gastroparesis (DGP) delays gastric emptying in diabetes patients, notably impacting those with type 1 and long-standing type 2 diabetes. Symptoms include early satiety, fullness, appetite loss, bloating, abdominal pain, and vomiting, arising from slow stomach-to-intestine food movement. DGP’s unpredictable nature complicates diagnosis and blood glucose management, leading to severe complications like dehydration, malnutrition, and bezoar formation. Understanding DGP’s mechanisms is crucial for effective management. Vagal dysfunction, disturbances in the interstitial cells of Cajal, reduced neural nitric oxide synthase, and increased oxidative stress contribute to the complex pathophysiology. Accurate diagnosis demands a comprehensive approach, utilizing tools like gastric scintigraphy and the Gastric Emptying Breath Test. Considering the complex relationship between DGP and glycemia, managing blood glucose levels becomes paramount. Nutritional interventions, tailored to each patient, address malnutrition risks, emphasizing smaller, more frequent meals and liquid consistency. DGP’s complex nature necessitates collaborative efforts for enhanced diagnostic strategies, improved pathophysiological understanding, and compassionate management approaches. This comprehensive approach offers hope for a future where individuals with DGP can experience improved well-being and quality of life. |
| first_indexed | 2024-04-24T18:14:20Z |
| format | Article |
| id | doaj.art-2c1e864b0ac743169db52e52c572f4aa |
| institution | Directory Open Access Journal |
| issn | 2624-5647 |
| language | English |
| last_indexed | 2024-04-24T18:14:20Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastrointestinal Disorders |
| spelling | doaj.art-2c1e864b0ac743169db52e52c572f4aa2024-03-27T13:42:32ZengMDPI AGGastrointestinal Disorders2624-56472024-02-016121422910.3390/gidisord6010016Diabetic Gastroparesis: Navigating Pathophysiology and Nutritional InterventionsAlfredo Caturano0Massimiliano Cavallo1Davide Nilo2Gaetano Vaudo3Vincenzo Russo4Raffaele Galiero5Luca Rinaldi6Raffaele Marfella7Marcellino Monda8Giovanni Luca9Ferdinando Carlo Sasso10Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, ItalyInternal Medicine Unit, Santa Maria Terni Hospital, I-05100 Terni, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, ItalyInternal Medicine Unit, Santa Maria Terni Hospital, I-05100 Terni, ItalyDepartment of Biology, College of Science and Technology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USADepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, I-86100 Campobasso, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, ItalyDepartment of Experimental Medicine, University of Campania Luigi Vanvitelli, I-80138 Naples, ItalyMedical Andrology and Reproductive Endocrinology Unit, Santa Maria Hospital, I-05100 Terni, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, I-80138 Naples, ItalyDiabetic gastroparesis (DGP) delays gastric emptying in diabetes patients, notably impacting those with type 1 and long-standing type 2 diabetes. Symptoms include early satiety, fullness, appetite loss, bloating, abdominal pain, and vomiting, arising from slow stomach-to-intestine food movement. DGP’s unpredictable nature complicates diagnosis and blood glucose management, leading to severe complications like dehydration, malnutrition, and bezoar formation. Understanding DGP’s mechanisms is crucial for effective management. Vagal dysfunction, disturbances in the interstitial cells of Cajal, reduced neural nitric oxide synthase, and increased oxidative stress contribute to the complex pathophysiology. Accurate diagnosis demands a comprehensive approach, utilizing tools like gastric scintigraphy and the Gastric Emptying Breath Test. Considering the complex relationship between DGP and glycemia, managing blood glucose levels becomes paramount. Nutritional interventions, tailored to each patient, address malnutrition risks, emphasizing smaller, more frequent meals and liquid consistency. DGP’s complex nature necessitates collaborative efforts for enhanced diagnostic strategies, improved pathophysiological understanding, and compassionate management approaches. This comprehensive approach offers hope for a future where individuals with DGP can experience improved well-being and quality of life.https://www.mdpi.com/2624-5647/6/1/16diabetic gastroparesisnutritional interventionpathophysiologydiabetesdiabetes complication |
| spellingShingle | Alfredo Caturano Massimiliano Cavallo Davide Nilo Gaetano Vaudo Vincenzo Russo Raffaele Galiero Luca Rinaldi Raffaele Marfella Marcellino Monda Giovanni Luca Ferdinando Carlo Sasso Diabetic Gastroparesis: Navigating Pathophysiology and Nutritional Interventions Gastrointestinal Disorders diabetic gastroparesis nutritional intervention pathophysiology diabetes diabetes complication |
| title | Diabetic Gastroparesis: Navigating Pathophysiology and Nutritional Interventions |
| title_full | Diabetic Gastroparesis: Navigating Pathophysiology and Nutritional Interventions |
| title_fullStr | Diabetic Gastroparesis: Navigating Pathophysiology and Nutritional Interventions |
| title_full_unstemmed | Diabetic Gastroparesis: Navigating Pathophysiology and Nutritional Interventions |
| title_short | Diabetic Gastroparesis: Navigating Pathophysiology and Nutritional Interventions |
| title_sort | diabetic gastroparesis navigating pathophysiology and nutritional interventions |
| topic | diabetic gastroparesis nutritional intervention pathophysiology diabetes diabetes complication |
| url | https://www.mdpi.com/2624-5647/6/1/16 |
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