Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects
Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed <i>Parthenium hysterophorus</i> (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacolo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/17/5347 |
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| author | Amarpreet Kaur Shalinder Kaur Rupali Jandrotia Harminder Pal Singh Daizy Rani Batish Ravinder Kumar Kohli Virendra Singh Rana Najam A. Shakil |
| author_facet | Amarpreet Kaur Shalinder Kaur Rupali Jandrotia Harminder Pal Singh Daizy Rani Batish Ravinder Kumar Kohli Virendra Singh Rana Najam A. Shakil |
| author_sort | Amarpreet Kaur |
| collection | DOAJ |
| description | Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed <i>Parthenium hysterophorus</i> (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of the plant. Thus far, parthenin and its derivatives have been tested for chemotherapeutic abilities, medicinal properties, and herbicidal/pesticidal activities. However, due to the lack of toxicity–bioactivity relationship studies, the versatile properties of parthenin are relatively less utilised. The possibility of exploiting parthenin in different scientific fields (e.g., chemistry, medicine, and agriculture) makes it a subject of analytical discussion. The present review highlights the multifaceted uses of parthenin, on-going research, constraints in the practical applicability, and the possible workarounds for its successful utilisation. The main aim of this comprehensive discussion is to bring parthenin to the attention of researchers, pharmacologists, natural product chemists, and chemical biologists and to open the door for its multidimensional applications. |
| first_indexed | 2024-03-10T08:05:40Z |
| format | Article |
| id | doaj.art-2c225c000dc3402883b6c6ccacffdb20 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:05:40Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2c225c000dc3402883b6c6ccacffdb202023-11-22T11:02:46ZengMDPI AGMolecules1420-30492021-09-012617534710.3390/molecules26175347Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and ProspectsAmarpreet Kaur0Shalinder Kaur1Rupali Jandrotia2Harminder Pal Singh3Daizy Rani Batish4Ravinder Kumar Kohli5Virendra Singh Rana6Najam A. Shakil7Department of Botany, Panjab University, Chandigarh 160 014, IndiaDepartment of Botany, Panjab University, Chandigarh 160 014, IndiaDepartment of Botany, Panjab University, Chandigarh 160 014, IndiaDepartment of Environment Studies, Panjab University, Chandigarh 160 014, IndiaDepartment of Botany, Panjab University, Chandigarh 160 014, IndiaDepartment of Botany, Panjab University, Chandigarh 160 014, IndiaDivision of Agricultural Chemicals, Indian Agricultural Research Institute, PUSA, New Delhi 110 012, IndiaDivision of Agricultural Chemicals, Indian Agricultural Research Institute, PUSA, New Delhi 110 012, IndiaParthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed <i>Parthenium hysterophorus</i> (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of the plant. Thus far, parthenin and its derivatives have been tested for chemotherapeutic abilities, medicinal properties, and herbicidal/pesticidal activities. However, due to the lack of toxicity–bioactivity relationship studies, the versatile properties of parthenin are relatively less utilised. The possibility of exploiting parthenin in different scientific fields (e.g., chemistry, medicine, and agriculture) makes it a subject of analytical discussion. The present review highlights the multifaceted uses of parthenin, on-going research, constraints in the practical applicability, and the possible workarounds for its successful utilisation. The main aim of this comprehensive discussion is to bring parthenin to the attention of researchers, pharmacologists, natural product chemists, and chemical biologists and to open the door for its multidimensional applications.https://www.mdpi.com/1420-3049/26/17/5347pharmacological propertiespseudoguaianolidesesquiterpene lactonetoxicologyterpenoids |
| spellingShingle | Amarpreet Kaur Shalinder Kaur Rupali Jandrotia Harminder Pal Singh Daizy Rani Batish Ravinder Kumar Kohli Virendra Singh Rana Najam A. Shakil Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects Molecules pharmacological properties pseudoguaianolide sesquiterpene lactone toxicology terpenoids |
| title | Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects |
| title_full | Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects |
| title_fullStr | Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects |
| title_full_unstemmed | Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects |
| title_short | Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects |
| title_sort | parthenin a sesquiterpene lactone with multifaceted biological activities insights and prospects |
| topic | pharmacological properties pseudoguaianolide sesquiterpene lactone toxicology terpenoids |
| url | https://www.mdpi.com/1420-3049/26/17/5347 |
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