The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding
Although dietary fiber treatment alters the gut microbiota and its metabolite production, it is unclear whether or not exercise habits can have a supplemental effect on changes in gut microbiota in dietary fiber-treated mice. To clarify the supplemental effect of voluntary exercise on gut microbiota...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/9/2508 |
| _version_ | 1797556906908188672 |
|---|---|
| author | Takafumi Aoki Eri Oyanagi Chihiro Watanabe Nanako Kobiki Suzuka Miura Yuka Yokogawa Hiromi Kitamura Fusako Teramoto Michael J. Kremenik Hiromi Yano |
| author_facet | Takafumi Aoki Eri Oyanagi Chihiro Watanabe Nanako Kobiki Suzuka Miura Yuka Yokogawa Hiromi Kitamura Fusako Teramoto Michael J. Kremenik Hiromi Yano |
| author_sort | Takafumi Aoki |
| collection | DOAJ |
| description | Although dietary fiber treatment alters the gut microbiota and its metabolite production, it is unclear whether or not exercise habits can have a supplemental effect on changes in gut microbiota in dietary fiber-treated mice. To clarify the supplemental effect of voluntary exercise on gut microbiota in partially hydrolyzed guar gum (PHGG), which is a soluble dietary fiber, treated mice under high-fat diet (HFD) feeding, 4-week-old male C57BL/6J mice (<i>n</i> = 80) were randomly divided into two dietary groups: the control-diet (CD) and HFD. Then, each dietary group was treated with or without PHGG, and with or without wheel running. After the experimental period, measurement of maximal oxygen consumption, a glucose tolerance test and fecal materials collection for analysis of gut microbiota were carried out. Voluntary exercise load in PHGG treatment under HFD feeding showed the supplemental effect of exercise on obesity (<i>p</i> < 0.01) and glucose tolerance (<i>p</i> < 0.01). Additionally, in both CD and HFD groups, voluntary exercise accelerated the decrease in the Firmicutes/Bacteroidetes ratio in mice fed with PHGG (<i>p</i> < 0.01). These findings suggest that voluntary exercise might activate the prevention of obesity and insulin resistance more via change in gut microbiota in mice administrated with PHGG. |
| first_indexed | 2024-03-10T17:09:44Z |
| format | Article |
| id | doaj.art-2c22cf71235549b08bbd50f531be1136 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T17:09:44Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-2c22cf71235549b08bbd50f531be11362023-11-20T10:41:04ZengMDPI AGNutrients2072-66432020-08-01129250810.3390/nu12092508The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet FeedingTakafumi Aoki0Eri Oyanagi1Chihiro Watanabe2Nanako Kobiki3Suzuka Miura4Yuka Yokogawa5Hiromi Kitamura6Fusako Teramoto7Michael J. Kremenik8Hiromi Yano9Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanDepartment of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanGraduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanDepartment of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanGraduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanGraduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanDepartment of Human Health, University of Marketing and Distribution Sciences, Kobe, Hyogo 651-2103, JapanGraduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanDepartment of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanGraduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanAlthough dietary fiber treatment alters the gut microbiota and its metabolite production, it is unclear whether or not exercise habits can have a supplemental effect on changes in gut microbiota in dietary fiber-treated mice. To clarify the supplemental effect of voluntary exercise on gut microbiota in partially hydrolyzed guar gum (PHGG), which is a soluble dietary fiber, treated mice under high-fat diet (HFD) feeding, 4-week-old male C57BL/6J mice (<i>n</i> = 80) were randomly divided into two dietary groups: the control-diet (CD) and HFD. Then, each dietary group was treated with or without PHGG, and with or without wheel running. After the experimental period, measurement of maximal oxygen consumption, a glucose tolerance test and fecal materials collection for analysis of gut microbiota were carried out. Voluntary exercise load in PHGG treatment under HFD feeding showed the supplemental effect of exercise on obesity (<i>p</i> < 0.01) and glucose tolerance (<i>p</i> < 0.01). Additionally, in both CD and HFD groups, voluntary exercise accelerated the decrease in the Firmicutes/Bacteroidetes ratio in mice fed with PHGG (<i>p</i> < 0.01). These findings suggest that voluntary exercise might activate the prevention of obesity and insulin resistance more via change in gut microbiota in mice administrated with PHGG.https://www.mdpi.com/2072-6643/12/9/2508dietary fiberwheel runningF/B ratio |
| spellingShingle | Takafumi Aoki Eri Oyanagi Chihiro Watanabe Nanako Kobiki Suzuka Miura Yuka Yokogawa Hiromi Kitamura Fusako Teramoto Michael J. Kremenik Hiromi Yano The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding Nutrients dietary fiber wheel running F/B ratio |
| title | The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding |
| title_full | The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding |
| title_fullStr | The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding |
| title_full_unstemmed | The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding |
| title_short | The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding |
| title_sort | effect of voluntary exercise on gut microbiota in partially hydrolyzed guar gum intake mice under high fat diet feeding |
| topic | dietary fiber wheel running F/B ratio |
| url | https://www.mdpi.com/2072-6643/12/9/2508 |
| work_keys_str_mv | AT takafumiaoki theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT erioyanagi theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT chihirowatanabe theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT nanakokobiki theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT suzukamiura theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT yukayokogawa theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT hiromikitamura theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT fusakoteramoto theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT michaeljkremenik theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT hiromiyano theeffectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT takafumiaoki effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT erioyanagi effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT chihirowatanabe effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT nanakokobiki effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT suzukamiura effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT yukayokogawa effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT hiromikitamura effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT fusakoteramoto effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT michaeljkremenik effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding AT hiromiyano effectofvoluntaryexerciseongutmicrobiotainpartiallyhydrolyzedguargumintakemiceunderhighfatdietfeeding |