HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis
Background: NAFLD is one of the most common liver diseases in the world. HOMA-IR as an indicator of insulin resistance is commonly used in clinical trials in NAFLD patients. The aim of this study was to evaluate the application of HOMA-IR index in the diagnosis of NAFLD. Methods: This study was perf...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2022-06-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-2695-en.html |
| _version_ | 1818532221269573632 |
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| author | Behrang Motamed Mahsa Kohansal Vajargah Saeed Kalantari Afshin Shafaghi |
| author_facet | Behrang Motamed Mahsa Kohansal Vajargah Saeed Kalantari Afshin Shafaghi |
| author_sort | Behrang Motamed |
| collection | DOAJ |
| description | Background: NAFLD is one of the most common liver diseases in the world. HOMA-IR as an indicator of insulin resistance is commonly used in clinical trials in NAFLD patients. The aim of this study was to evaluate the application of HOMA-IR index in the diagnosis of NAFLD.
Methods: This study was performed on 54 patients with NAFLD and 54 non-NAFLD patients that referred to Razi Hospital in Rasht during 2019-2020. FibroScan was used to diagnose NAFLD in the patient group and ultrasound was used to rule it out in the control group. Metabolic and hepatic parameters were measured for each patient. Data were entered into SPSS 22 software and the necessary analyses were performed.
Results: The mean age of the subjects in the study was 44.01±13.12 years and ranged from 18 to 75 years. 72.2% of people affected by NAFLD were men (p <0.001) .The optimal cut-off point for HOMA-IR in NAFLD was 1.65 with a sensitivity of 89.7% and a specificity of 76.9% in men and 1.90 with a sensitivity of 86.7% and a specificity of 82.9% in women. Overall, the optimal cut-off point for HOMA-IR in NAFLD was 1.75 with a sensitivity of 87.0% and a specificity of 81.5%. In addition, the results showed that there was no significant relationship between steatosis and hepatic fibrosis with HOMA-IR index.
Conclusion: The results showed that HOMA-IR can be used as a reliable criterion for early detection of NAFLD. |
| first_indexed | 2024-12-11T17:42:40Z |
| format | Article |
| id | doaj.art-2c2369613e744c04b336723abb805561 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-12-11T17:42:40Z |
| publishDate | 2022-06-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-2c2369613e744c04b336723abb8055612022-12-22T00:56:28ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722022-06-01133519526HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosisBehrang Motamed0Mahsa Kohansal Vajargah1Saeed Kalantari2Afshin Shafaghi3 Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, Iran GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran Background: NAFLD is one of the most common liver diseases in the world. HOMA-IR as an indicator of insulin resistance is commonly used in clinical trials in NAFLD patients. The aim of this study was to evaluate the application of HOMA-IR index in the diagnosis of NAFLD. Methods: This study was performed on 54 patients with NAFLD and 54 non-NAFLD patients that referred to Razi Hospital in Rasht during 2019-2020. FibroScan was used to diagnose NAFLD in the patient group and ultrasound was used to rule it out in the control group. Metabolic and hepatic parameters were measured for each patient. Data were entered into SPSS 22 software and the necessary analyses were performed. Results: The mean age of the subjects in the study was 44.01±13.12 years and ranged from 18 to 75 years. 72.2% of people affected by NAFLD were men (p <0.001) .The optimal cut-off point for HOMA-IR in NAFLD was 1.65 with a sensitivity of 89.7% and a specificity of 76.9% in men and 1.90 with a sensitivity of 86.7% and a specificity of 82.9% in women. Overall, the optimal cut-off point for HOMA-IR in NAFLD was 1.75 with a sensitivity of 87.0% and a specificity of 81.5%. In addition, the results showed that there was no significant relationship between steatosis and hepatic fibrosis with HOMA-IR index. Conclusion: The results showed that HOMA-IR can be used as a reliable criterion for early detection of NAFLD.http://caspjim.com/article-1-2695-en.htmlnafldhoma-irinsulin resistancefibroscanbmi. |
| spellingShingle | Behrang Motamed Mahsa Kohansal Vajargah Saeed Kalantari Afshin Shafaghi HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis Caspian Journal of Internal Medicine nafld homa-ir insulin resistance fibroscan bmi. |
| title | HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis |
| title_full | HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis |
| title_fullStr | HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis |
| title_full_unstemmed | HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis |
| title_short | HOMA-IR index in non diabetic patient, a reliable method for early diagnosis of liver steatosis |
| title_sort | homa ir index in non diabetic patient a reliable method for early diagnosis of liver steatosis |
| topic | nafld homa-ir insulin resistance fibroscan bmi. |
| url | http://caspjim.com/article-1-2695-en.html |
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