Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantationResearch in context

Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantationResearch in context

Summary: Background: Innate immunity plays a fundamental role in solid organ transplantation. Myeloid cells can sense danger signals or DAMPs released after tissue or cell damage, such as during ischemia processes. This study aimed to identify DAMPs released during cold ischemia storage of human li...

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Bibliographic Details
Main Authors: Fernando Lucas-Ruiz, Sandra V. Mateo, Marta Jover-Aguilar, Felipe Alconchel, Laura Martínez-Alarcón, Carlos de Torre-Minguela, Daniel Vidal-Correoso, Francisco Villalba-López, Víctor López-López, Antonio Ríos-Zambudio, José A. Pons, Pablo Ramírez, Pablo Pelegrín, Alberto Baroja-Mazo
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:EBioMedicine
Subjects:
DAMPs
NLRP3
Inflammasome
Cold ischemia
DCD
DBD
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422006016

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