Increased absolute lymphocyte count, increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory/relapsing gynecologic malignancies with anti PD-1 therapy: 10 years of experience in a single institution
Objective: Immune checkpoint inhibitors are rapidly being used in solid and hematologic malignancies, including gynecologic cancers. The high mortality and relapsing rates of advanced gynecologic malignancies remain a challenging issue. This study aimed to identify the predicting factors associated...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455923001213 |
| _version_ | 1797787242851205120 |
|---|---|
| author | Wan-Ju Lee Yi-Lun Wang Hsiu-Huei Peng Cheng-Tao Lin |
| author_facet | Wan-Ju Lee Yi-Lun Wang Hsiu-Huei Peng Cheng-Tao Lin |
| author_sort | Wan-Ju Lee |
| collection | DOAJ |
| description | Objective: Immune checkpoint inhibitors are rapidly being used in solid and hematologic malignancies, including gynecologic cancers. The high mortality and relapsing rates of advanced gynecologic malignancies remain a challenging issue. This study aimed to identify the predicting factors associated with survival prognosis and disease control in patients with refractory/relapsing (R/R) gynecologic malignancies receiving anti PD-1 therapy. Materials and methods: We retrospectively reviewed the medical records of 49 patients diagnosed with R/R gynecologic malignancies between July 2012 and June 2019 in Chang Gung Memorial Hospital, Taiwan. Among the 49 patients, 6 were excluded due to incomplete medical records or not receiving anti PD-1 therapy. The remaining 43 patients were further divided into responsive and non-responsive groups according to disease control for predicting prognostic factor analysis. Results: For the 43 cases, the median age at diagnosis and disease follow-up length were 54 years and 29 months, respectively. Among them, 23 (53%) were categorized into the responsive group, and the remaining 20 (47%) were categorized into the non-responsive group. The mortality rates were 17% and 25% in the responsive and non-responsive groups, respectively. The responsive group had significantly higher absolute lymphocyte count (ALC), higher absolute neutrophil count (ANC) and low platelet to lymphocyte ratio (PLR) than the non-responsive group. A superior long-term survival trend was also observed in the responsive group, but the difference was not statistically significant. Conclusions: This study reinforced the hypothesis that high ALC, high ANC and low PLR are associated with superior disease control in patients with R/R gynecologic malignancies receiving anti PD-1 therapy. |
| first_indexed | 2024-03-13T01:19:14Z |
| format | Article |
| id | doaj.art-2c2adc59355e44ac8792e85eb06a94ab |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-03-13T01:19:14Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-2c2adc59355e44ac8792e85eb06a94ab2023-07-05T05:14:54ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592023-07-01624506509Increased absolute lymphocyte count, increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory/relapsing gynecologic malignancies with anti PD-1 therapy: 10 years of experience in a single institutionWan-Ju Lee0Yi-Lun Wang1Hsiu-Huei Peng2Cheng-Tao Lin3Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Linkou Medical Center, Taoyuan, TaiwanDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Linkou Medical Center, Taoyuan, Taiwan; Corresponding author. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine 5, Fu-Hsin Street, Kwei Shan, Taoyuan, 333, Taiwan. Fax: +886-3-328-6700.Objective: Immune checkpoint inhibitors are rapidly being used in solid and hematologic malignancies, including gynecologic cancers. The high mortality and relapsing rates of advanced gynecologic malignancies remain a challenging issue. This study aimed to identify the predicting factors associated with survival prognosis and disease control in patients with refractory/relapsing (R/R) gynecologic malignancies receiving anti PD-1 therapy. Materials and methods: We retrospectively reviewed the medical records of 49 patients diagnosed with R/R gynecologic malignancies between July 2012 and June 2019 in Chang Gung Memorial Hospital, Taiwan. Among the 49 patients, 6 were excluded due to incomplete medical records or not receiving anti PD-1 therapy. The remaining 43 patients were further divided into responsive and non-responsive groups according to disease control for predicting prognostic factor analysis. Results: For the 43 cases, the median age at diagnosis and disease follow-up length were 54 years and 29 months, respectively. Among them, 23 (53%) were categorized into the responsive group, and the remaining 20 (47%) were categorized into the non-responsive group. The mortality rates were 17% and 25% in the responsive and non-responsive groups, respectively. The responsive group had significantly higher absolute lymphocyte count (ALC), higher absolute neutrophil count (ANC) and low platelet to lymphocyte ratio (PLR) than the non-responsive group. A superior long-term survival trend was also observed in the responsive group, but the difference was not statistically significant. Conclusions: This study reinforced the hypothesis that high ALC, high ANC and low PLR are associated with superior disease control in patients with R/R gynecologic malignancies receiving anti PD-1 therapy.http://www.sciencedirect.com/science/article/pii/S1028455923001213Gynecologic malignanciesImmune checkpoint inhibitorAbsolute lymphocyte countAbsolute neutrophil countPlatelet to lymphocyte ratio |
| spellingShingle | Wan-Ju Lee Yi-Lun Wang Hsiu-Huei Peng Cheng-Tao Lin Increased absolute lymphocyte count, increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory/relapsing gynecologic malignancies with anti PD-1 therapy: 10 years of experience in a single institution Taiwanese Journal of Obstetrics & Gynecology Gynecologic malignancies Immune checkpoint inhibitor Absolute lymphocyte count Absolute neutrophil count Platelet to lymphocyte ratio |
| title | Increased absolute lymphocyte count, increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory/relapsing gynecologic malignancies with anti PD-1 therapy: 10 years of experience in a single institution |
| title_full | Increased absolute lymphocyte count, increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory/relapsing gynecologic malignancies with anti PD-1 therapy: 10 years of experience in a single institution |
| title_fullStr | Increased absolute lymphocyte count, increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory/relapsing gynecologic malignancies with anti PD-1 therapy: 10 years of experience in a single institution |
| title_full_unstemmed | Increased absolute lymphocyte count, increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory/relapsing gynecologic malignancies with anti PD-1 therapy: 10 years of experience in a single institution |
| title_short | Increased absolute lymphocyte count, increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory/relapsing gynecologic malignancies with anti PD-1 therapy: 10 years of experience in a single institution |
| title_sort | increased absolute lymphocyte count increased absolute neutrophil count and low platelet to lymphocyte ratio as predicting factors in the superior disease control of refractory relapsing gynecologic malignancies with anti pd 1 therapy 10 years of experience in a single institution |
| topic | Gynecologic malignancies Immune checkpoint inhibitor Absolute lymphocyte count Absolute neutrophil count Platelet to lymphocyte ratio |
| url | http://www.sciencedirect.com/science/article/pii/S1028455923001213 |
| work_keys_str_mv | AT wanjulee increasedabsolutelymphocytecountincreasedabsoluteneutrophilcountandlowplatelettolymphocyteratioaspredictingfactorsinthesuperiordiseasecontrolofrefractoryrelapsinggynecologicmalignancieswithantipd1therapy10yearsofexperienceinasingleinstitution AT yilunwang increasedabsolutelymphocytecountincreasedabsoluteneutrophilcountandlowplatelettolymphocyteratioaspredictingfactorsinthesuperiordiseasecontrolofrefractoryrelapsinggynecologicmalignancieswithantipd1therapy10yearsofexperienceinasingleinstitution AT hsiuhueipeng increasedabsolutelymphocytecountincreasedabsoluteneutrophilcountandlowplatelettolymphocyteratioaspredictingfactorsinthesuperiordiseasecontrolofrefractoryrelapsinggynecologicmalignancieswithantipd1therapy10yearsofexperienceinasingleinstitution AT chengtaolin increasedabsolutelymphocytecountincreasedabsoluteneutrophilcountandlowplatelettolymphocyteratioaspredictingfactorsinthesuperiordiseasecontrolofrefractoryrelapsinggynecologicmalignancieswithantipd1therapy10yearsofexperienceinasingleinstitution |