Cost effectiveness of OptiMal<sup>® </sup>rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil
<p>Abstract</p> <p>Background</p> <p>In areas with limited structure in place for microscopy diagnosis, rapid diagnostic tests (RDT) have been demonstrated to be effective.</p> <p>Method</p> <p>The cost-effectiveness of the Optimal<sup>® &l...
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| Format: | Article |
| Language: | English |
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BMC
2010-10-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/9/1/277 |
| _version_ | 1828299436633096192 |
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| author | Toscano Cristiana M de Castro Gomes Almério de Oliveira Maria |
| author_facet | Toscano Cristiana M de Castro Gomes Almério de Oliveira Maria |
| author_sort | Toscano Cristiana M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In areas with limited structure in place for microscopy diagnosis, rapid diagnostic tests (RDT) have been demonstrated to be effective.</p> <p>Method</p> <p>The cost-effectiveness of the Optimal<sup>® </sup>and thick smear microscopy was estimated and compared. Data were collected on remote areas of 12 municipalities in the Brazilian Amazon. Data sources included the National Malaria Control Programme of the Ministry of Health, the National Healthcare System reimbursement table, hospitalization records, primary data collected from the municipalities, and scientific literature. The perspective was that of the Brazilian public health system, the analytical horizon was from the start of fever until the diagnostic results provided to patient and the temporal reference was that of year 2006. The results were expressed in costs per adequately diagnosed cases in 2006 U.S. dollars. Sensitivity analysis was performed considering key model parameters.</p> <p>Results</p> <p>In the case base scenario, considering 92% and 95% sensitivity for thick smear microscopy to <it>Plasmodium falciparum </it>and <it>Plasmodium vivax</it>, respectively, and 100% specificity for both species, thick smear microscopy is more costly and more effective, with an incremental cost estimated at US$549.9 per adequately diagnosed case. In sensitivity analysis, when sensitivity and specificity of microscopy for <it>P. vivax </it>were 0.90 and 0.98, respectively, and when its sensitivity for <it>P. falciparum </it>was 0.83, the RDT was more cost-effective than microscopy.</p> <p>Conclusion</p> <p>Microscopy is more cost-effective than OptiMal<sup>® </sup>in these remote areas if high accuracy of microscopy is maintained in the field. Decision regarding use of rapid tests for diagnosis of malaria in these areas depends on current microscopy accuracy in the field.</p> |
| first_indexed | 2024-04-13T12:55:36Z |
| format | Article |
| id | doaj.art-2c2b93fcee144c78a78585495882aa7a |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-13T12:55:36Z |
| publishDate | 2010-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-2c2b93fcee144c78a78585495882aa7a2022-12-22T02:46:05ZengBMCMalaria Journal1475-28752010-10-019127710.1186/1475-2875-9-277Cost effectiveness of OptiMal<sup>® </sup>rapid diagnostic test for malaria in remote areas of the Amazon Region, BrazilToscano Cristiana Mde Castro Gomes Almériode Oliveira Maria<p>Abstract</p> <p>Background</p> <p>In areas with limited structure in place for microscopy diagnosis, rapid diagnostic tests (RDT) have been demonstrated to be effective.</p> <p>Method</p> <p>The cost-effectiveness of the Optimal<sup>® </sup>and thick smear microscopy was estimated and compared. Data were collected on remote areas of 12 municipalities in the Brazilian Amazon. Data sources included the National Malaria Control Programme of the Ministry of Health, the National Healthcare System reimbursement table, hospitalization records, primary data collected from the municipalities, and scientific literature. The perspective was that of the Brazilian public health system, the analytical horizon was from the start of fever until the diagnostic results provided to patient and the temporal reference was that of year 2006. The results were expressed in costs per adequately diagnosed cases in 2006 U.S. dollars. Sensitivity analysis was performed considering key model parameters.</p> <p>Results</p> <p>In the case base scenario, considering 92% and 95% sensitivity for thick smear microscopy to <it>Plasmodium falciparum </it>and <it>Plasmodium vivax</it>, respectively, and 100% specificity for both species, thick smear microscopy is more costly and more effective, with an incremental cost estimated at US$549.9 per adequately diagnosed case. In sensitivity analysis, when sensitivity and specificity of microscopy for <it>P. vivax </it>were 0.90 and 0.98, respectively, and when its sensitivity for <it>P. falciparum </it>was 0.83, the RDT was more cost-effective than microscopy.</p> <p>Conclusion</p> <p>Microscopy is more cost-effective than OptiMal<sup>® </sup>in these remote areas if high accuracy of microscopy is maintained in the field. Decision regarding use of rapid tests for diagnosis of malaria in these areas depends on current microscopy accuracy in the field.</p>http://www.malariajournal.com/content/9/1/277 |
| spellingShingle | Toscano Cristiana M de Castro Gomes Almério de Oliveira Maria Cost effectiveness of OptiMal<sup>® </sup>rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil Malaria Journal |
| title | Cost effectiveness of OptiMal<sup>® </sup>rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil |
| title_full | Cost effectiveness of OptiMal<sup>® </sup>rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil |
| title_fullStr | Cost effectiveness of OptiMal<sup>® </sup>rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil |
| title_full_unstemmed | Cost effectiveness of OptiMal<sup>® </sup>rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil |
| title_short | Cost effectiveness of OptiMal<sup>® </sup>rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil |
| title_sort | cost effectiveness of optimal sup r sup rapid diagnostic test for malaria in remote areas of the amazon region brazil |
| url | http://www.malariajournal.com/content/9/1/277 |
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