Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration

Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration

Protein aggregation is an important feature of neurodegenerative disorders. In Alzheimer's disease (AD) protein aggregates are composed of hyperphosphorylated Tau and amyloid beta peptide (Aβ). Despite the involvement and identification of the molecular composition of these aggregates, their ro...

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Bibliographic Details
Main Authors:	Rodrigo S. Chaves, Amajad I. Kazi, Carolliny M. Silva, Michael F. Almeida, Raquel S. Lima, Daniel C. Carrettiero, Marilene Demasi, Merari F.R. Ferrari
Format:	Article
Language:	English
Published:	Elsevier 2016-12-01
Series:	IBRO Reports
Subjects:	Hyperphosphorylated Tau Hippocampus Rotenone Oxidative stress Proteasome activity Autophagy flux Protein aggregation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2451830116300073

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