Subclinical Neck Pain Leads to Differential Changes in Early Somatosensory Evoked Potentials in Response to a Novel Force Matching Tracking Task
Background: Neural adaptions in response to sensorimotor tasks are impaired in those with untreated, recurrent mild-to-moderate neck pain (subclinical neck pain (SCNP)), due to disordered central processing of afferent information (e.g., proprioception). Neural adaption to force modulation, a sensor...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2024-01-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301010 |
| _version_ | 1797338803098091520 |
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| author | Ushani Ambalavanar Paul Yielder Heather S. McCracken Hailey Tabbert Bernadette Murphy |
| author_facet | Ushani Ambalavanar Paul Yielder Heather S. McCracken Hailey Tabbert Bernadette Murphy |
| author_sort | Ushani Ambalavanar |
| collection | DOAJ |
| description | Background: Neural adaptions in response to sensorimotor tasks are impaired in those with untreated, recurrent mild-to-moderate neck pain (subclinical neck pain (SCNP)), due to disordered central processing of afferent information (e.g., proprioception). Neural adaption to force modulation, a sensorimotor skill reliant on accurate proprioception, is likely to be impaired in those with SCNP. This study examined changes in somatosensory evoked potential (SEP) peak amplitudes following the acquisition of a novel force matching tracking task (FMTT) in those with SCNP compared to non-SCNP. Methods: 40 (20 female (F) & 20 male (M); average age (standard deviation, SD): 21.6 (3.01)) right-handed participants received controlled electrical stimulation at 2.47 Hz and 4.98 Hz (averaged 1000 sweeps/frequency) over the right-median nerve, to elicit SEPs before and after FMTT acquisition. Participants used their right thumb to match a series of force profiles that were calibrated to their right thumb (abductor pollicis brevis muscle) strength. To determine if motor learning was impacted, retention was assessed 24 to 48 hours later. Outliers were removed before running independent t-tests on normalized SEP peak amplitudes, and repeated measures analysis of variance (ANOVA) with planned contrasts on absolute and normalized motor performance accuracy. Benjamini-hochberg test was used to correct for multiple independent SEP comparisons. Results: SEP peaks: N18 (t(29.058) = 2.031, p = 0.026), N20 (t(35) = –5.460, p < 0.001), and P25 (t(33) = –2.857, p = 0.004) had group differences. Motor performance: Absolute error (n = 38) had a main effect of time, and significant pre-and post-acquisition contrast for time (both p < 0.001). Conclusions: Group differences in the olivary-cerebellar pathway (N18), and cortical processing at the somatosensory cortex (N20 and P25), suggests that SCNP alters cortical and cerebellar processing compared to non-SCNP in response to FMTT acquisition. The sensory-motor integration differences in the SCNP group suggests that those with SCNP may rely more on feedback loops for discrete sensorimotor tasks dependent on proprioception. Early SEP changes may be used as a marker for altered neuroplasticity in the context of motor skill acquisition of a novel discrete FMTT in those with SCNP. |
| first_indexed | 2024-03-08T09:36:34Z |
| format | Article |
| id | doaj.art-2c2d62d5fa414e92831ab49d9a6a2065 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-08T09:36:34Z |
| publishDate | 2024-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-2c2d62d5fa414e92831ab49d9a6a20652024-01-30T07:44:43ZengIMR PressJournal of Integrative Neuroscience0219-63522024-01-012311010.31083/j.jin2301010S0219-6352(23)00647-2Subclinical Neck Pain Leads to Differential Changes in Early Somatosensory Evoked Potentials in Response to a Novel Force Matching Tracking TaskUshani Ambalavanar0Paul Yielder1Heather S. McCracken2Hailey Tabbert3Bernadette Murphy4Faculty of Health Sciences, University of Ontario Institute of Technology (Ontario Tech University), Oshawa, ON L1G 0C5, CanadaFaculty of Health Sciences, University of Ontario Institute of Technology (Ontario Tech University), Oshawa, ON L1G 0C5, CanadaFaculty of Health Sciences, University of Ontario Institute of Technology (Ontario Tech University), Oshawa, ON L1G 0C5, CanadaFaculty of Health Sciences, University of Ontario Institute of Technology (Ontario Tech University), Oshawa, ON L1G 0C5, CanadaFaculty of Health Sciences, University of Ontario Institute of Technology (Ontario Tech University), Oshawa, ON L1G 0C5, CanadaBackground: Neural adaptions in response to sensorimotor tasks are impaired in those with untreated, recurrent mild-to-moderate neck pain (subclinical neck pain (SCNP)), due to disordered central processing of afferent information (e.g., proprioception). Neural adaption to force modulation, a sensorimotor skill reliant on accurate proprioception, is likely to be impaired in those with SCNP. This study examined changes in somatosensory evoked potential (SEP) peak amplitudes following the acquisition of a novel force matching tracking task (FMTT) in those with SCNP compared to non-SCNP. Methods: 40 (20 female (F) & 20 male (M); average age (standard deviation, SD): 21.6 (3.01)) right-handed participants received controlled electrical stimulation at 2.47 Hz and 4.98 Hz (averaged 1000 sweeps/frequency) over the right-median nerve, to elicit SEPs before and after FMTT acquisition. Participants used their right thumb to match a series of force profiles that were calibrated to their right thumb (abductor pollicis brevis muscle) strength. To determine if motor learning was impacted, retention was assessed 24 to 48 hours later. Outliers were removed before running independent t-tests on normalized SEP peak amplitudes, and repeated measures analysis of variance (ANOVA) with planned contrasts on absolute and normalized motor performance accuracy. Benjamini-hochberg test was used to correct for multiple independent SEP comparisons. Results: SEP peaks: N18 (t(29.058) = 2.031, p = 0.026), N20 (t(35) = –5.460, p < 0.001), and P25 (t(33) = –2.857, p = 0.004) had group differences. Motor performance: Absolute error (n = 38) had a main effect of time, and significant pre-and post-acquisition contrast for time (both p < 0.001). Conclusions: Group differences in the olivary-cerebellar pathway (N18), and cortical processing at the somatosensory cortex (N20 and P25), suggests that SCNP alters cortical and cerebellar processing compared to non-SCNP in response to FMTT acquisition. The sensory-motor integration differences in the SCNP group suggests that those with SCNP may rely more on feedback loops for discrete sensorimotor tasks dependent on proprioception. Early SEP changes may be used as a marker for altered neuroplasticity in the context of motor skill acquisition of a novel discrete FMTT in those with SCNP.https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301010neck dysfunctioncerebellar processingcortical processingsensorimotor integrationmotor performancesomatosensory evoked potentials |
| spellingShingle | Ushani Ambalavanar Paul Yielder Heather S. McCracken Hailey Tabbert Bernadette Murphy Subclinical Neck Pain Leads to Differential Changes in Early Somatosensory Evoked Potentials in Response to a Novel Force Matching Tracking Task Journal of Integrative Neuroscience neck dysfunction cerebellar processing cortical processing sensorimotor integration motor performance somatosensory evoked potentials |
| title | Subclinical Neck Pain Leads to Differential Changes in Early Somatosensory Evoked Potentials in Response to a Novel Force Matching Tracking Task |
| title_full | Subclinical Neck Pain Leads to Differential Changes in Early Somatosensory Evoked Potentials in Response to a Novel Force Matching Tracking Task |
| title_fullStr | Subclinical Neck Pain Leads to Differential Changes in Early Somatosensory Evoked Potentials in Response to a Novel Force Matching Tracking Task |
| title_full_unstemmed | Subclinical Neck Pain Leads to Differential Changes in Early Somatosensory Evoked Potentials in Response to a Novel Force Matching Tracking Task |
| title_short | Subclinical Neck Pain Leads to Differential Changes in Early Somatosensory Evoked Potentials in Response to a Novel Force Matching Tracking Task |
| title_sort | subclinical neck pain leads to differential changes in early somatosensory evoked potentials in response to a novel force matching tracking task |
| topic | neck dysfunction cerebellar processing cortical processing sensorimotor integration motor performance somatosensory evoked potentials |
| url | https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301010 |
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