Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation[S]

Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation[S]

ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate. Although an association between elevated levels of ACSL4 and hepatosteatosis has been reported, the function of ACSL4 in hepatic FA metabolism and the regulation...

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Bibliographic Details
Main Authors: Chin Fung Kelvin Kan, Amar Bahadur Singh, Diana M. Stafforini, Salman Azhar, Jingwen Liu
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Journal of Lipid Research
Subjects:
posttranslational regulation
proteasome
nonalcoholic fatty liver disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520353293

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