The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling

The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling

Abstract Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogenetic protein) co-receptor that promotes and shapes BMP signaling. MuSK is expressed at all neuromuscular junctions and is also present extrasynaptically in the mouse sol...

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Bibliographic Details
Main Authors: Diego Jaime, Lauren A. Fish, Laura A. Madigan, Chengjie Xi, Giorgia Piccoli, Madison D. Ewing, Bert Blaauw, Justin R. Fallon
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Skeletal Muscle
Subjects:
MuSK
Atrophy
Cachexia
mTOR
BMP
IGF1
Online Access:https://doi.org/10.1186/s13395-023-00329-9

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