Network analysis, in vivo, and in vitro experiments identified the mechanisms by which Piper longum L. [Piperaceae] alleviates cartilage destruction, joint inflammation, and arthritic pain

Network analysis, in vivo, and in vitro experiments identified the mechanisms by which Piper longum L. [Piperaceae] alleviates cartilage destruction, joint inflammation, and arthritic pain

Osteoarthritis (OA) is characterized by irreversible joint destruction, pain, and dysfunction. Piper longum L. [Piperaceae] (PL) is an East Asian herbal medicine with reported anti-inflammatory, analgesic, antioxidant, anti-stress, and anti-osteoporotic effects. This study aimed to evaluate the effi...

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Bibliographic Details
Main Authors: Hee Geun Jo, Chae Yun Baek, Donghwan Kim, Sangjin Kim, Yewon Han, Chanlim Park, Ho Sueb Song, Donghun Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
Piper longum L. [Piperaceae]
network analysis
experimental verification
osteoarthritis
East Asian herbal medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1282943/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1282943/full

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