Photodynamic Therapy: Current Trends and Potential Future Role in the Treatment of Bladder Cancer
Bladder cancer (BC) is the 10th most common cancer in the world. The therapeutic spectrum of BC is broad and is constantly expanding. Despite the wide clinical use of photodynamic diagnosis (PTD) for BC, PDT has not been sufficiently investigated in the treatment landscape of BC. We performed an onl...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/2/960 |
| _version_ | 1797339798908698624 |
|---|---|
| author | Maxim Kochergin Omar Fahmy Anastasios Asimakopoulos Gerit Theil Kathleen Zietz Johanna Bialek Eugenio Tiberi Georgios Gakis |
| author_facet | Maxim Kochergin Omar Fahmy Anastasios Asimakopoulos Gerit Theil Kathleen Zietz Johanna Bialek Eugenio Tiberi Georgios Gakis |
| author_sort | Maxim Kochergin |
| collection | DOAJ |
| description | Bladder cancer (BC) is the 10th most common cancer in the world. The therapeutic spectrum of BC is broad and is constantly expanding. Despite the wide clinical use of photodynamic diagnosis (PTD) for BC, PDT has not been sufficiently investigated in the treatment landscape of BC. We performed an online search of the PubMed database using these keywords: <i>photodynamic therapy</i>, <i>bladder cancer</i>, <i>urothelial carcinoma</i>, in vivo, in vitro, <i>cell line</i>, <i>animal model.</i> Reviews, case reports, and articles devoted to photodynamic diagnostics and the photodynamic therapy of tumors other than urothelial carcinoma were excluded. Of a total of 695 publications, we selected 20 articles with clinical data, 34 articles on in vivo PDT, and 106 articles on in vitro data. The results presented in animal models highlight the potential use of PDT in the neoadjuvant or adjuvant setting to reduce local recurrence in the bladder and upper urinary tracts. Possible regimens include the combination of PDT with intravesical chemotherapy for improved local tumor control or the integration of vascular-targeted PDT in combination with modern systemic drugs in order to boost local response. We summarize available evidence on the preclinical and clinical application of PDT for urothelial carcinoma in order to explain the current trends and future perspectives. |
| first_indexed | 2024-03-08T09:53:37Z |
| format | Article |
| id | doaj.art-2c2fdd7edf4745aaba59f5f3d0f0d3f1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:53:37Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2c2fdd7edf4745aaba59f5f3d0f0d3f12024-01-29T13:55:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-0125296010.3390/ijms25020960Photodynamic Therapy: Current Trends and Potential Future Role in the Treatment of Bladder CancerMaxim Kochergin0Omar Fahmy1Anastasios Asimakopoulos2Gerit Theil3Kathleen Zietz4Johanna Bialek5Eugenio Tiberi6Georgios Gakis7Department of Urology and Neurourology, BG Unfallkrankenhaus Berlin, 12683 Berlin, GermanyDepartment of Urology, Universiti Putra Malaysia (UPM), Serdang 43400, MalaysiaUrology Unit, Fondazione PTV Policlinico Tor Vergata, 00133 Rome, ItalyUniversity Clinic and Polyclinic of Urology, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, 06099 Halle, GermanyUniversity Clinic and Polyclinic of Urology, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, 06099 Halle, GermanyUniversity Clinic and Polyclinic of Urology, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, 06099 Halle, GermanyDepartment of Urology and Neurourology, BG Unfallkrankenhaus Berlin, 12683 Berlin, GermanyUniversity Clinic and Polyclinic of Urology, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, 06099 Halle, GermanyBladder cancer (BC) is the 10th most common cancer in the world. The therapeutic spectrum of BC is broad and is constantly expanding. Despite the wide clinical use of photodynamic diagnosis (PTD) for BC, PDT has not been sufficiently investigated in the treatment landscape of BC. We performed an online search of the PubMed database using these keywords: <i>photodynamic therapy</i>, <i>bladder cancer</i>, <i>urothelial carcinoma</i>, in vivo, in vitro, <i>cell line</i>, <i>animal model.</i> Reviews, case reports, and articles devoted to photodynamic diagnostics and the photodynamic therapy of tumors other than urothelial carcinoma were excluded. Of a total of 695 publications, we selected 20 articles with clinical data, 34 articles on in vivo PDT, and 106 articles on in vitro data. The results presented in animal models highlight the potential use of PDT in the neoadjuvant or adjuvant setting to reduce local recurrence in the bladder and upper urinary tracts. Possible regimens include the combination of PDT with intravesical chemotherapy for improved local tumor control or the integration of vascular-targeted PDT in combination with modern systemic drugs in order to boost local response. We summarize available evidence on the preclinical and clinical application of PDT for urothelial carcinoma in order to explain the current trends and future perspectives.https://www.mdpi.com/1422-0067/25/2/960photodynamic therapybladder cancerurothelial carcinomain vivoin vitrocell line |
| spellingShingle | Maxim Kochergin Omar Fahmy Anastasios Asimakopoulos Gerit Theil Kathleen Zietz Johanna Bialek Eugenio Tiberi Georgios Gakis Photodynamic Therapy: Current Trends and Potential Future Role in the Treatment of Bladder Cancer International Journal of Molecular Sciences photodynamic therapy bladder cancer urothelial carcinoma in vivo in vitro cell line |
| title | Photodynamic Therapy: Current Trends and Potential Future Role in the Treatment of Bladder Cancer |
| title_full | Photodynamic Therapy: Current Trends and Potential Future Role in the Treatment of Bladder Cancer |
| title_fullStr | Photodynamic Therapy: Current Trends and Potential Future Role in the Treatment of Bladder Cancer |
| title_full_unstemmed | Photodynamic Therapy: Current Trends and Potential Future Role in the Treatment of Bladder Cancer |
| title_short | Photodynamic Therapy: Current Trends and Potential Future Role in the Treatment of Bladder Cancer |
| title_sort | photodynamic therapy current trends and potential future role in the treatment of bladder cancer |
| topic | photodynamic therapy bladder cancer urothelial carcinoma in vivo in vitro cell line |
| url | https://www.mdpi.com/1422-0067/25/2/960 |
| work_keys_str_mv | AT maximkochergin photodynamictherapycurrenttrendsandpotentialfutureroleinthetreatmentofbladdercancer AT omarfahmy photodynamictherapycurrenttrendsandpotentialfutureroleinthetreatmentofbladdercancer AT anastasiosasimakopoulos photodynamictherapycurrenttrendsandpotentialfutureroleinthetreatmentofbladdercancer AT gerittheil photodynamictherapycurrenttrendsandpotentialfutureroleinthetreatmentofbladdercancer AT kathleenzietz photodynamictherapycurrenttrendsandpotentialfutureroleinthetreatmentofbladdercancer AT johannabialek photodynamictherapycurrenttrendsandpotentialfutureroleinthetreatmentofbladdercancer AT eugeniotiberi photodynamictherapycurrenttrendsandpotentialfutureroleinthetreatmentofbladdercancer AT georgiosgakis photodynamictherapycurrenttrendsandpotentialfutureroleinthetreatmentofbladdercancer |