Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins

Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins

The interaction between the Spike (S) protein of SARS-CoV-2 and the human angiotensin converting enzyme 2 (hACE2) is essential for infection, and is a target for neutralizing antibodies. Consequently, selection of mutations in the S protein is expected to be driven by the impact on the interaction w...

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Bibliographic Details
Main Authors: Victor Barozi, Adrienne L. Edkins, Özlem Tastan Bishop
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Centrality metrics
Comparative essential dynamics
Dynamic residue network analysis
MDM-TASK-web
Mutation analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003506

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