Specific Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of Adaptive Immune System Components
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is modifying human activity all over the world with significant health and economic burden. The advent of the SARS-CoV-2 pandemic prompted the scientific community to learn the virus dynam...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.856657/full |
| _version_ | 1811271648961101824 |
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| author | Rosalia Busà Maria Concetta Sorrentino Giovanna Russelli Giandomenico Amico Giandomenico Amico Vitale Miceli Monica Miele Monica Miele Mariangela Di Bella Mariangela Di Bella Francesca Timoneri Francesca Timoneri Alessia Gallo Giovanni Zito Daniele Di Carlo Pier Giulio Conaldi Matteo Bulati |
| author_facet | Rosalia Busà Maria Concetta Sorrentino Giovanna Russelli Giandomenico Amico Giandomenico Amico Vitale Miceli Monica Miele Monica Miele Mariangela Di Bella Mariangela Di Bella Francesca Timoneri Francesca Timoneri Alessia Gallo Giovanni Zito Daniele Di Carlo Pier Giulio Conaldi Matteo Bulati |
| author_sort | Rosalia Busà |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is modifying human activity all over the world with significant health and economic burden. The advent of the SARS-CoV-2 pandemic prompted the scientific community to learn the virus dynamics concerning transmissibility, epidemiology, and usefulness of vaccines in fighting emerging health hazards. Pieces of evidence suggest that the first and second doses of mRNA vaccines induce a significant antibody response in vaccinated subjects or patients who recovered from SARS-CoV-2 infection, demonstrating the importance of the previously formed memory. The aim of this work has been to investigate the effects of BNT162b2 Pfizer-BioNTech mRNA-based vaccine booster dose in a cohort of 11 uninfected immunocompetent (ICs), evaluating the humoral and cellular responses, with more carefulness on memory B and T cells. Our findings underscore the potential benefit of the third dose of mRNA vaccine on the lifespan of memory B and T cells, suggesting that booster doses could increase protection against SARS-CoV-2 infection. |
| first_indexed | 2024-04-12T22:23:42Z |
| format | Article |
| id | doaj.art-2c31a6fe0ca74f3ba5aae68127fa79e3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T22:23:42Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2c31a6fe0ca74f3ba5aae68127fa79e32022-12-22T03:14:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.856657856657Specific Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of Adaptive Immune System ComponentsRosalia Busà0Maria Concetta Sorrentino1Giovanna Russelli2Giandomenico Amico3Giandomenico Amico4Vitale Miceli5Monica Miele6Monica Miele7Mariangela Di Bella8Mariangela Di Bella9Francesca Timoneri10Francesca Timoneri11Alessia Gallo12Giovanni Zito13Daniele Di Carlo14Pier Giulio Conaldi15Matteo Bulati16Research Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyDepartment of Laboratory Medicine and Advanced Biotechnologies, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyDepartment of Regenerative Medicine, Ri.MED Foundation, Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyDepartment of Regenerative Medicine, Ri.MED Foundation, Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyDepartment of Regenerative Medicine, Ri.MED Foundation, Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyDepartment of Regenerative Medicine, Ri.MED Foundation, Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyDepartment of Laboratory Medicine and Advanced Biotechnologies, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalyResearch Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, ItalySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is modifying human activity all over the world with significant health and economic burden. The advent of the SARS-CoV-2 pandemic prompted the scientific community to learn the virus dynamics concerning transmissibility, epidemiology, and usefulness of vaccines in fighting emerging health hazards. Pieces of evidence suggest that the first and second doses of mRNA vaccines induce a significant antibody response in vaccinated subjects or patients who recovered from SARS-CoV-2 infection, demonstrating the importance of the previously formed memory. The aim of this work has been to investigate the effects of BNT162b2 Pfizer-BioNTech mRNA-based vaccine booster dose in a cohort of 11 uninfected immunocompetent (ICs), evaluating the humoral and cellular responses, with more carefulness on memory B and T cells. Our findings underscore the potential benefit of the third dose of mRNA vaccine on the lifespan of memory B and T cells, suggesting that booster doses could increase protection against SARS-CoV-2 infection.https://www.frontiersin.org/articles/10.3389/fimmu.2022.856657/fullSARS-CoV-2mRNA vaccineBNT162b2booster doseB cellsT cells |
| spellingShingle | Rosalia Busà Maria Concetta Sorrentino Giovanna Russelli Giandomenico Amico Giandomenico Amico Vitale Miceli Monica Miele Monica Miele Mariangela Di Bella Mariangela Di Bella Francesca Timoneri Francesca Timoneri Alessia Gallo Giovanni Zito Daniele Di Carlo Pier Giulio Conaldi Matteo Bulati Specific Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of Adaptive Immune System Components Frontiers in Immunology SARS-CoV-2 mRNA vaccine BNT162b2 booster dose B cells T cells |
| title | Specific Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of Adaptive Immune System Components |
| title_full | Specific Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of Adaptive Immune System Components |
| title_fullStr | Specific Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of Adaptive Immune System Components |
| title_full_unstemmed | Specific Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of Adaptive Immune System Components |
| title_short | Specific Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of Adaptive Immune System Components |
| title_sort | specific anti sars cov 2 humoral and cellular immune responses after booster dose of bnt162b2 pfizer biontech mrna based vaccine integrated study of adaptive immune system components |
| topic | SARS-CoV-2 mRNA vaccine BNT162b2 booster dose B cells T cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.856657/full |
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