Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration.
The depletion times of the anticoccidial nicarbazin administered individually and of nicarbazin and narasin administered in combination were evaluated by determining the presence and levels of 4,4'-dinitrocarbanilide (DNC), the marker residue for nicarbazin, and narasin residues in the muscle t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5531545?pdf=render |
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| author | Arina Lopes de Lima Fabiano Barreto Renata Batista Rau Guilherme Resende da Silva Leonardo José Camargos Lara Tadeu Chaves de Figueiredo Débora Cristina Sampaio de Assis Silvana de Vasconcelos Cançado |
| author_facet | Arina Lopes de Lima Fabiano Barreto Renata Batista Rau Guilherme Resende da Silva Leonardo José Camargos Lara Tadeu Chaves de Figueiredo Débora Cristina Sampaio de Assis Silvana de Vasconcelos Cançado |
| author_sort | Arina Lopes de Lima |
| collection | DOAJ |
| description | The depletion times of the anticoccidial nicarbazin administered individually and of nicarbazin and narasin administered in combination were evaluated by determining the presence and levels of 4,4'-dinitrocarbanilide (DNC), the marker residue for nicarbazin, and narasin residues in the muscle tissues of broiler chickens subjected to a pharmacological treatment. A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was used. The results showed the presence of all anticoccidial residues; however, the DNC levels were higher when the nicarbazin was administered individually than when it was used in association with narasin throughout the experimental period. After six days of withdrawal, the DNC level following nicarbazin administration alone was lower than the maximum residue level (MRL) of 200 μg kg-1. However, when the nicarbazin was co-administered with narasin, the concentrations of DNC were lower than the MRL after four days of withdrawal. These results may be justified because the dosage of nicarbazin, when administrated individually, is greater than when it is used in combination with narasin. The levels of narasin were lower than the MRL of 15 μg kg-1 throughout the evaluation period. It was concluded that nicarbazin is rapidly metabolized from the broiler muscles up to six days of withdrawal since the DNC levels were lower than the maximum residue level (MRL) and the concentrations of narasin were lower than the MRL throughout the evaluation period. |
| first_indexed | 2024-12-12T17:37:08Z |
| format | Article |
| id | doaj.art-2c324a5e61e443bf894f4e0d653cfee7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T17:37:08Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2c324a5e61e443bf894f4e0d653cfee72022-12-22T00:17:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018175510.1371/journal.pone.0181755Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration.Arina Lopes de LimaFabiano BarretoRenata Batista RauGuilherme Resende da SilvaLeonardo José Camargos LaraTadeu Chaves de FigueiredoDébora Cristina Sampaio de AssisSilvana de Vasconcelos CançadoThe depletion times of the anticoccidial nicarbazin administered individually and of nicarbazin and narasin administered in combination were evaluated by determining the presence and levels of 4,4'-dinitrocarbanilide (DNC), the marker residue for nicarbazin, and narasin residues in the muscle tissues of broiler chickens subjected to a pharmacological treatment. A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was used. The results showed the presence of all anticoccidial residues; however, the DNC levels were higher when the nicarbazin was administered individually than when it was used in association with narasin throughout the experimental period. After six days of withdrawal, the DNC level following nicarbazin administration alone was lower than the maximum residue level (MRL) of 200 μg kg-1. However, when the nicarbazin was co-administered with narasin, the concentrations of DNC were lower than the MRL after four days of withdrawal. These results may be justified because the dosage of nicarbazin, when administrated individually, is greater than when it is used in combination with narasin. The levels of narasin were lower than the MRL of 15 μg kg-1 throughout the evaluation period. It was concluded that nicarbazin is rapidly metabolized from the broiler muscles up to six days of withdrawal since the DNC levels were lower than the maximum residue level (MRL) and the concentrations of narasin were lower than the MRL throughout the evaluation period.http://europepmc.org/articles/PMC5531545?pdf=render |
| spellingShingle | Arina Lopes de Lima Fabiano Barreto Renata Batista Rau Guilherme Resende da Silva Leonardo José Camargos Lara Tadeu Chaves de Figueiredo Débora Cristina Sampaio de Assis Silvana de Vasconcelos Cançado Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration. PLoS ONE |
| title | Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration. |
| title_full | Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration. |
| title_fullStr | Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration. |
| title_full_unstemmed | Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration. |
| title_short | Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration. |
| title_sort | determination of the residue levels of nicarbazin and combination nicarbazin narasin in broiler chickens after oral administration |
| url | http://europepmc.org/articles/PMC5531545?pdf=render |
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