Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory
Previous studies evidenced that a portion of normotensive Sprague–Dawley rats spontaneously exhibit lower baroreflex sensitivity, however, it was no yet investigated in Wistar rats. We aimed to compare baroreflex sensitivity among rats from the same strain and the same laboratory. Male Wistar normot...
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| Format: | Article |
| Language: | English |
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Touch Medical Media
2011-09-01
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| Series: | Heart International |
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| Online Access: | http://www.pagepress.org/journals/index.php/hi/article/view/2528 |
| _version_ | 1819063122415058944 |
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| author | Celso Ferreira Oseas F. Moura Filho Hugo Macedo Junior Luiz Carlos de Abreu Vitor E. Valenti |
| author_facet | Celso Ferreira Oseas F. Moura Filho Hugo Macedo Junior Luiz Carlos de Abreu Vitor E. Valenti |
| author_sort | Celso Ferreira |
| collection | DOAJ |
| description | Previous studies evidenced that a portion of normotensive Sprague–Dawley rats spontaneously exhibit lower baroreflex sensitivity, however, it was no yet investigated in Wistar rats. We aimed to compare baroreflex sensitivity among rats from the same strain and the same laboratory. Male Wistar normotensive rats (300-400g) were studied. Cannulas were inserted into the abdominal aortic artery through the right femoral artery to measure mean arterial pressure and heart rate. Baroreflex was calculated as the derivative of the variation of heart rate in function of the mean arterial pressure variation (ΔHR/ΔMAP) tested with a depressor dose of sodium nitroprusside (50 μg/kg) and with a pressor dose of phenylephrine (8μg/kg) in the right femoral venous approach through an inserted cannula. We divided the rats into four groups: i) high bradycardic baroreflex, baroreflex gain less than -2 tested with phenylephrine; ii) low bradycardic baroreflex, baroreflex gain between -1 and -2 tested with phenylephrine; iii) high tachycardic baroreflex, baroreflex gain less than -3 tested with sodium nitroprusside; and iv) low tachycardic baroreflex, baroreflex gain between -1 and -3 tested with sodium nitroprusside. Approximately 71% of the rats presented a decrease in bradycardic reflex while around half showed an increase in tachycardic reflex. No significant changes in basal mean arterial pressure and heart rate, tachycardic and bradycardic peak and heart rate range were observed. There was a significant change in baroreflex sensitivity among rats from the same strain and the same laboratory. |
| first_indexed | 2024-12-21T15:09:39Z |
| format | Article |
| id | doaj.art-2c332b487dc746438ac716fbf415c314 |
| institution | Directory Open Access Journal |
| issn | 1826-1868 2036-2579 |
| language | English |
| last_indexed | 2024-12-21T15:09:39Z |
| publishDate | 2011-09-01 |
| publisher | Touch Medical Media |
| record_format | Article |
| series | Heart International |
| spelling | doaj.art-2c332b487dc746438ac716fbf415c3142022-12-21T18:59:19ZengTouch Medical MediaHeart International1826-18682036-25792011-09-0162e9e910.4081/hi.2011.e9Baroreflex sensitivity differs among same strain Wistar rats from the same laboratoryCelso FerreiraOseas F. Moura FilhoHugo Macedo JuniorLuiz Carlos de AbreuVitor E. ValentiPrevious studies evidenced that a portion of normotensive Sprague–Dawley rats spontaneously exhibit lower baroreflex sensitivity, however, it was no yet investigated in Wistar rats. We aimed to compare baroreflex sensitivity among rats from the same strain and the same laboratory. Male Wistar normotensive rats (300-400g) were studied. Cannulas were inserted into the abdominal aortic artery through the right femoral artery to measure mean arterial pressure and heart rate. Baroreflex was calculated as the derivative of the variation of heart rate in function of the mean arterial pressure variation (ΔHR/ΔMAP) tested with a depressor dose of sodium nitroprusside (50 μg/kg) and with a pressor dose of phenylephrine (8μg/kg) in the right femoral venous approach through an inserted cannula. We divided the rats into four groups: i) high bradycardic baroreflex, baroreflex gain less than -2 tested with phenylephrine; ii) low bradycardic baroreflex, baroreflex gain between -1 and -2 tested with phenylephrine; iii) high tachycardic baroreflex, baroreflex gain less than -3 tested with sodium nitroprusside; and iv) low tachycardic baroreflex, baroreflex gain between -1 and -3 tested with sodium nitroprusside. Approximately 71% of the rats presented a decrease in bradycardic reflex while around half showed an increase in tachycardic reflex. No significant changes in basal mean arterial pressure and heart rate, tachycardic and bradycardic peak and heart rate range were observed. There was a significant change in baroreflex sensitivity among rats from the same strain and the same laboratory.http://www.pagepress.org/journals/index.php/hi/article/view/2528baroreceptors, hypertension, autonomic nervous system, parasympathetic nerve, sympathetic nerve |
| spellingShingle | Celso Ferreira Oseas F. Moura Filho Hugo Macedo Junior Luiz Carlos de Abreu Vitor E. Valenti Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory Heart International baroreceptors, hypertension, autonomic nervous system, parasympathetic nerve, sympathetic nerve |
| title | Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory |
| title_full | Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory |
| title_fullStr | Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory |
| title_full_unstemmed | Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory |
| title_short | Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory |
| title_sort | baroreflex sensitivity differs among same strain wistar rats from the same laboratory |
| topic | baroreceptors, hypertension, autonomic nervous system, parasympathetic nerve, sympathetic nerve |
| url | http://www.pagepress.org/journals/index.php/hi/article/view/2528 |
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