Acid Catalyzed <i>N</i>-Alkylation of Pyrazoles with Trichloroacetimidates

Acid Catalyzed <i>N</i>-Alkylation of Pyrazoles with Trichloroacetimidates

<i>N</i>-Alkyl pyrazoles are important heterocycles in organic and medicinal chemistry, demonstrating a wide range of biological activity. A new method for the <i>N</i>-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles and a Brønsted acid cat...

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Bibliographic Details
Main Authors: Rowan I. L. Meador, Nilamber A. Mate, John D. Chisholm
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Organics
Subjects:
pyrazole
trichloroacetimidate
alkylation
acid
catalysis
Online Access:https://www.mdpi.com/2673-401X/3/2/9

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