IDH1 K224 acetylation promotes colorectal cancer via miR-9-5p/NHE1 axis-mediated regulation of acidic microenvironment

IDH1 K224 acetylation promotes colorectal cancer via miR-9-5p/NHE1 axis-mediated regulation of acidic microenvironment

Summary: The acidic microenvironment is considered an important factor in colorectal cancer (CRC) that contributes to malignant transformation. However, the underlying mechanism remains unclear. In a previous study, we confirmed that IDH1 K224 deacetylation promotes enzymatic activity and the produc...

Full description

Bibliographic Details
Main Authors:	Bo Wang, Long Zhao, Changjiang Yang, Yilin Lin, Shan Wang, Yingjiang Ye, Jianyuan Luo, Zhanlong Shen
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Series:	iScience
Subjects:	Cell biology Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S258900422301283X

Similar Items

Biomarkers for immune checkpoint inhibitors in colorectal cancer: recent advances and future perspectives
by: Changjiang Yang, et al.
Published: (2023-09-01)

Application of Single-Cell Sequencing Technology in Research on Colorectal Cancer
by: Long Zhao, et al.
Published: (2024-01-01)

Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway
by: Shuang Peng, et al.
Published: (2023-07-01)

Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics
by: Joi Weeks, et al.
Published: (2021-05-01)

Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes.
by: Tattersall, A, et al.
Published: (2008)

FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report
by: Fang Jia, et al.
Published: (2023-02-01)

An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment
by: Bing Yang, et al.
Published: (2022-03-01)

Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis
by: Yan-Qi Yang, et al.
Published: (2022-09-01)

Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
by: Yuqi Zhang, et al.
Published: (2022-10-01)

P224: Using long-read sequencing for genomic and epigenomic analysis in patient-derived samples with somatic IDH1 mosaicism
by: Carolina Montano, et al.
Published: (2024-01-01)

Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
by: Wang Ximin, et al.
Published: (2023-05-01)

The New Role of HNF1A-NAS1/miR-214/INHBA Signaling Axis in Colorectal Cancer
by: Xuan Zhang, et al.
Published: (2023-11-01)

Prognostic Biomarker SPOCD1 and Its Correlation with Immune Infiltrates in Colorectal Cancer
by: Lin Gan, et al.
Published: (2023-01-01)

circ_0008285 Regulates Glioma Progression via the miR-384/HMGB1 Axis
by: Manli Yan, et al.
Published: (2023-01-01)

Role of ELK1 in regulating colorectal cancer progression: miR-31-5p/CDIP1 axis in CRC pathogenesis
by: Guoqiang Yan, et al.
Published: (2023-07-01)

Early diagnostic evaluation of miR-122 and miR-224 as biomarkers for hepatocellular carcinoma
by: Khalda S. Amr, et al.
Published: (2017-12-01)

Up-regulated expression of NHE1 and Netrin-1 in atherosclerotic plaque of ApoE-/-mice
by: YANG Hui, MO Xian-gang, WANG Lan, ZHANG Shi-yue
Published: (2020-06-01)

Cuproptosis patterns and tumor immune infiltration characterization in colorectal cancer
by: Yan Du, et al.
Published: (2022-09-01)

miR551b Regulates Colorectal Cancer Progression by Targeting the ZEB1 Signaling Axis
by: Kwang Seock Kim, et al.
Published: (2019-05-01)

Knockdown of circSOD2 ameliorates osteoarthritis progression via the miR-224-5p/PRDX3 axis
by: Hao Li, et al.
Published: (2023-06-01)

MiR-506 Targets UHRF1 to Inhibit Colorectal Cancer Proliferation and Invasion via the KISS1/PI3K/NF-κB Signaling Axis
by: Yilin Lin, et al.
Published: (2019-11-01)

Long Non-Coding RNA TRG-AS1 Promoted Proliferation and Invasion of Lung Cancer Cells Through the miR-224-5p/SMAD4 Axis [Retraction]
by: Zhang M, et al.
Published: (2024-04-01)

Circ_0001535 Facilitates Tumor Malignant Progression by miR-485-5p/LASP1 Axis in Colorectal Cancer
by: Liang Bai, et al.
Published: (2022-11-01)

Empagliflozin mitigates cardiac hypertrophy through cardiac RSK/NHE-1 inhibition
by: Sha Chen, et al.
Published: (2024-05-01)

Mitochondrial NHE1: A newly identified target to prevent heart disease
by: BERNARDO VICTOR ALVAREZ, et al.
Published: (2013-06-01)

SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis
by: Xiao-Wei Wang, et al.
Published: (2023-12-01)

Empagliflozin prevents oxidative stress in human coronary artery endothelial cells via the NHE/PKC/NOX axis
by: Xiaoling Li, et al.
Published: (2024-02-01)

Concurrent IDH1 and IDH2 mutations in glioblastoma: A case report
by: Ali S. Haider, et al.
Published: (2023-04-01)

GENETIC BIOMARKERS OF GLIAL BRAIN TUMORS: IDH1 AND IDH2 MUTATIONS
by: M. Yu. Prokudin, et al.
Published: (2020-09-01)

IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution
by: Erika F. Rodriguez, et al.
Published: (2020-06-01)

Hsa_circ_0009092/miR-665/NLK signaling axis suppresses colorectal cancer progression via recruiting TAMs in the tumor microenvironment
by: Jialin Song, et al.
Published: (2023-11-01)

Presencia de los genes de toxigenicidad nheA, nheBy nheC en cepas de Bacillus cereus aisladas de leches deshidratadas en Costa Rica
by: Jonathan Rojas, et al.

Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma.
by: Krell, D, et al.
Published: (2011)

Quercetin’s Dual Mode of Action to Counteract the Sp1-miR-27a Axis in Colorectal Cancer Cells
by: Emanuele Fosso, et al.
Published: (2023-08-01)

MiRNAs from the Dlk1-Dio3 locus and miR-224/452 cluster contribute to glioblastoma tumor heterogeneity
by: Christopher M. Smith, et al.
Published: (2024-04-01)

Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells
by: Dandan Fan, et al.
Published: (2021-01-01)

DICER1-AS1 Promotes the Malignant Behaviors of Colorectal Cancer Cells by Regulating miR-296-5p/STAT3 Axis
by: Ma C, et al.
Published: (2020-10-01)

IDH1: Linking metabolism and epigenetics
by: Raineri, S, et al.
Published: (2018)

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
by: Emir, U, et al.
Published: (2015)

Long non-coding RNA DCST1-AS1/hsa-miR-582-5p/HMGB1 axis regulates colorectal cancer progression
by: Long huang, et al.
Published: (2022-01-01)