Rituximab pediatric drug development: Pharmacokinetic and pharmacodynamic modeling to inform regulatory approval for rituximab treatment in patients with granulomatosis with polyangiitis or microscopic polyangiitis

Rituximab pediatric drug development: Pharmacokinetic and pharmacodynamic modeling to inform regulatory approval for rituximab treatment in patients with granulomatosis with polyangiitis or microscopic polyangiitis

Abstract Anti‐neutrophil cytoplasmic antibody‐associated vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare, potentially organ‐ and life‐threatening autoimmune conditions affecting adult and pediatric patients. An open‐label phase II study was conducted t...

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Bibliographic Details
Main Authors:	Candice Jamois, Leonid Gibiansky, Clarisse Chavanne, Melissa Cheu, Patricia B. Lehane, Pooneh Pordeli, Simone Melega, Jacques Gaudreault
Format:	Article
Language:	English
Published:	Wiley 2022-09-01
Series:	Clinical and Translational Science
Online Access:	https://doi.org/10.1111/cts.13351

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