Emerging role of transforming growth factor-β-regulated long non-coding RNAs in prostate cancer pathogenesis
Prostate cancer (PCa) is the most common malignancy in men. Despite aggressive therapy involving surgery and hormonal treatments, the recurrence and emergence of metastatic castration-resistant prostate cancer (CRPCa) remain a major challenge. Dysregulation of the transforming growth factor-β (TGF-β...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Cancer Pathogenesis and Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S294971322200026X |
| _version_ | 1797753875860553728 |
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| author | Bakhya Shree Koyel Das Vivek Sharma |
| author_facet | Bakhya Shree Koyel Das Vivek Sharma |
| author_sort | Bakhya Shree |
| collection | DOAJ |
| description | Prostate cancer (PCa) is the most common malignancy in men. Despite aggressive therapy involving surgery and hormonal treatments, the recurrence and emergence of metastatic castration-resistant prostate cancer (CRPCa) remain a major challenge. Dysregulation of the transforming growth factor-β (TGF-β) signaling pathway is crucial to PCa development and progression. This also contributes to androgen receptor activation and the emergence of CRPC. In addition, TGF-β signaling regulates long non-coding RNA (lncRNA) expression in multiple cancers, including PCa. Here, we discuss the complex regulatory network of lncRNAs and TGF-β signaling in PCa and their potential applications in diagnosing, prognosis, and treating PCa. Further investigations on the role of lncRNAs in the TGF-β pathway will help to better understand PCa pathogenesis. |
| first_indexed | 2024-03-12T17:24:11Z |
| format | Article |
| id | doaj.art-2c3569dacedb45c48434ff573847b597 |
| institution | Directory Open Access Journal |
| issn | 2949-7132 |
| language | English |
| last_indexed | 2024-03-12T17:24:11Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Pathogenesis and Therapy |
| spelling | doaj.art-2c3569dacedb45c48434ff573847b5972023-08-05T05:18:36ZengElsevierCancer Pathogenesis and Therapy2949-71322023-07-0113195204Emerging role of transforming growth factor-β-regulated long non-coding RNAs in prostate cancer pathogenesisBakhya Shree0Koyel Das1Vivek Sharma2Corresponding author: Department of Biological Sciences, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Hyderabad 500078, India.; Department of Biological Sciences, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Hyderabad 500078, IndiaDepartment of Biological Sciences, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Hyderabad 500078, IndiaCorresponding author: Department of Biological Sciences, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Hyderabad 500078, India.; Department of Biological Sciences, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Hyderabad 500078, IndiaProstate cancer (PCa) is the most common malignancy in men. Despite aggressive therapy involving surgery and hormonal treatments, the recurrence and emergence of metastatic castration-resistant prostate cancer (CRPCa) remain a major challenge. Dysregulation of the transforming growth factor-β (TGF-β) signaling pathway is crucial to PCa development and progression. This also contributes to androgen receptor activation and the emergence of CRPC. In addition, TGF-β signaling regulates long non-coding RNA (lncRNA) expression in multiple cancers, including PCa. Here, we discuss the complex regulatory network of lncRNAs and TGF-β signaling in PCa and their potential applications in diagnosing, prognosis, and treating PCa. Further investigations on the role of lncRNAs in the TGF-β pathway will help to better understand PCa pathogenesis.http://www.sciencedirect.com/science/article/pii/S294971322200026XProstate cancerTGF-βLncRNACastration-resistant prostate cancerAndrogen deprivation therapyAndrogen-independent prostate cancer |
| spellingShingle | Bakhya Shree Koyel Das Vivek Sharma Emerging role of transforming growth factor-β-regulated long non-coding RNAs in prostate cancer pathogenesis Cancer Pathogenesis and Therapy Prostate cancer TGF-β LncRNA Castration-resistant prostate cancer Androgen deprivation therapy Androgen-independent prostate cancer |
| title | Emerging role of transforming growth factor-β-regulated long non-coding RNAs in prostate cancer pathogenesis |
| title_full | Emerging role of transforming growth factor-β-regulated long non-coding RNAs in prostate cancer pathogenesis |
| title_fullStr | Emerging role of transforming growth factor-β-regulated long non-coding RNAs in prostate cancer pathogenesis |
| title_full_unstemmed | Emerging role of transforming growth factor-β-regulated long non-coding RNAs in prostate cancer pathogenesis |
| title_short | Emerging role of transforming growth factor-β-regulated long non-coding RNAs in prostate cancer pathogenesis |
| title_sort | emerging role of transforming growth factor β regulated long non coding rnas in prostate cancer pathogenesis |
| topic | Prostate cancer TGF-β LncRNA Castration-resistant prostate cancer Androgen deprivation therapy Androgen-independent prostate cancer |
| url | http://www.sciencedirect.com/science/article/pii/S294971322200026X |
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