Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis
This meta-analysis investigated the significant association between human leukocyte antigen (HLA)-G 14-bp insertion/deletion and +3142G>C polymorphisms with susceptibility to rheumatoid arthritis (RA). This relationship has been scrutinized in several studies, and the findings are controversial....
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Health Sciences and Biomedical Research KLEU |
| Subjects: | |
| Online Access: | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2022;volume=15;issue=2;spage=114;epage=120;aulast=Chowdhury |
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| author | Animesh Chowdhury Manoj Lama |
| author_facet | Animesh Chowdhury Manoj Lama |
| author_sort | Animesh Chowdhury |
| collection | DOAJ |
| description | This meta-analysis investigated the significant association between human leukocyte antigen (HLA)-G 14-bp insertion/deletion and +3142G>C polymorphisms with susceptibility to rheumatoid arthritis (RA). This relationship has been scrutinized in several studies, and the findings are controversial. The association studies related to HLA-G gene polymorphisms and RA were extracted from PubMed, Mendeley, ScienceDirect, and Google Scholar databases up to December 31, 2020. Finally, a total of 1516 cases and 1683 control samples were chosen from 7 published research articles for this meta-analysis. A significant association was evaluated using the pooled odds ratios (ORs) and 95% confidence intervals (CIs) under allelic, dominant, recessive, and additive models. Overall, there is absence of significant association between 14-bp ins/del polymorphism and RA (recessive model: OR = 1.012, 95% CI = 0.841–1.217, P = 0.900; dominant model: OR = 1.068, 95% CI = 0.919–1.241, P = 0.393; ins/ins vs. del/del: OR = 1.059, 95% CI = 0.861–1.303, P = 0.587). In the case of +3142G>C polymorphism, the recessive model (OR = 1.332, 95% CI = 1.083–1.640, P = 0.007) showed a significant association with RA susceptibility. When subgroup analysis was done by ethnicity, +3142G>C polymorphism was found to be significantly associated with RA susceptibility in the Asian population under the recessive model (OR = 1.450, 95% CI = 1.048–2.006, P = 0.025). This meta-analysis brings to light that there was no significant association between 14-bp ins/del polymorphism and RA susceptibility. Whereas, +3142G>C polymorphism was found to be significantly associated with susceptibility to RA. |
| first_indexed | 2024-04-13T21:53:29Z |
| format | Article |
| id | doaj.art-2c36199c7c6b416fad654bad6e6d56d2 |
| institution | Directory Open Access Journal |
| issn | 2542-6214 2542-6222 |
| language | English |
| last_indexed | 2024-04-13T21:53:29Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Health Sciences and Biomedical Research KLEU |
| spelling | doaj.art-2c36199c7c6b416fad654bad6e6d56d22022-12-22T02:28:21ZengWolters Kluwer Medknow PublicationsIndian Journal of Health Sciences and Biomedical Research KLEU2542-62142542-62222022-01-0115211412010.4103/kleuhsj.kleuhsj_391_21Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysisAnimesh ChowdhuryManoj LamaThis meta-analysis investigated the significant association between human leukocyte antigen (HLA)-G 14-bp insertion/deletion and +3142G>C polymorphisms with susceptibility to rheumatoid arthritis (RA). This relationship has been scrutinized in several studies, and the findings are controversial. The association studies related to HLA-G gene polymorphisms and RA were extracted from PubMed, Mendeley, ScienceDirect, and Google Scholar databases up to December 31, 2020. Finally, a total of 1516 cases and 1683 control samples were chosen from 7 published research articles for this meta-analysis. A significant association was evaluated using the pooled odds ratios (ORs) and 95% confidence intervals (CIs) under allelic, dominant, recessive, and additive models. Overall, there is absence of significant association between 14-bp ins/del polymorphism and RA (recessive model: OR = 1.012, 95% CI = 0.841–1.217, P = 0.900; dominant model: OR = 1.068, 95% CI = 0.919–1.241, P = 0.393; ins/ins vs. del/del: OR = 1.059, 95% CI = 0.861–1.303, P = 0.587). In the case of +3142G>C polymorphism, the recessive model (OR = 1.332, 95% CI = 1.083–1.640, P = 0.007) showed a significant association with RA susceptibility. When subgroup analysis was done by ethnicity, +3142G>C polymorphism was found to be significantly associated with RA susceptibility in the Asian population under the recessive model (OR = 1.450, 95% CI = 1.048–2.006, P = 0.025). This meta-analysis brings to light that there was no significant association between 14-bp ins/del polymorphism and RA susceptibility. Whereas, +3142G>C polymorphism was found to be significantly associated with susceptibility to RA.http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2022;volume=15;issue=2;spage=114;epage=120;aulast=Chowdhury+3142g>c14-bp ins/delhuman leukocyte antigen-gmeta-analysispolymorphismrheumatoid arthritis |
| spellingShingle | Animesh Chowdhury Manoj Lama Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis Indian Journal of Health Sciences and Biomedical Research KLEU +3142g>c 14-bp ins/del human leukocyte antigen-g meta-analysis polymorphism rheumatoid arthritis |
| title | Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis |
| title_full | Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis |
| title_fullStr | Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis |
| title_full_unstemmed | Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis |
| title_short | Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis |
| title_sort | association of human leukocyte antigen g 14 bp insertion deletion and 3142g c polymorphisms with rheumatoid arthritis a meta analysis |
| topic | +3142g>c 14-bp ins/del human leukocyte antigen-g meta-analysis polymorphism rheumatoid arthritis |
| url | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2022;volume=15;issue=2;spage=114;epage=120;aulast=Chowdhury |
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