Reduced Number and Immune Dysfunction of CD4+ T Cells in Obesity Accelerate Colorectal Cancer Progression

Reduced Number and Immune Dysfunction of CD4+ T Cells in Obesity Accelerate Colorectal Cancer Progression

Obesity, a known risk factor for various types of cancer, reduces the number and function of cytotoxic immune cells in the tumor immune microenvironment (TIME). However, the impact of obesity on CD4+ T cells remains unclear. Therefore, this study aimed to clarify the impact of obesity on CD4+ T cell...

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Bibliographic Details
Main Authors: Kota Yamada, Masafumi Saito, Masayuki Ando, Tomoki Abe, Tomosuke Mukoyama, Kyosuke Agawa, Akihiro Watanabe, Shiki Takamura, Mitsugu Fujita, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji, Kimihiro Yamashita
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
obesity
colorectal cancer
high-fat diet
CD4+ T cell
tumor immune microenvironment
Online Access:https://www.mdpi.com/2073-4409/12/1/86

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