Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regions
Individuals born preterm are at risk of developing a variety of sequelae. Audiovisual integration (AVI) has received little attention despite its facilitating role in the development of socio-cognitive abilities. The present study assessed the association between prematurity and in-vivo reconstructe...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323000075 |
| _version_ | 1797843830060351488 |
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| author | Juan F. Quinones Andrea Hildebrandt Tommaso Pavan Christiane M. Thiel Axel Heep |
| author_facet | Juan F. Quinones Andrea Hildebrandt Tommaso Pavan Christiane M. Thiel Axel Heep |
| author_sort | Juan F. Quinones |
| collection | DOAJ |
| description | Individuals born preterm are at risk of developing a variety of sequelae. Audiovisual integration (AVI) has received little attention despite its facilitating role in the development of socio-cognitive abilities. The present study assessed the association between prematurity and in-vivo reconstructed fiber bundles among brain regions relevant for AVI. We retrieved data from 63 preterm neonates enrolled in the Developing Human Connectome Project (http://www.developingconnectome.org/) and matched them with 63 term-born neonates from the same study by means of propensity score matching. We performed probabilistic tractography, DTI and NODDI analysis on the traced fibers. We found that specific DTI and NODDI metrics are significantly associated with prematurity in neonates matched for postmenstrual age at scan. We investigated the spatial overlap and developmental order of the reconstructed tractograms between preterm and full-term neonates. Permutation-based analysis revealed significant differences in dice similarity coefficients and developmental order between preterm and full term neonates at the group level. Contrarily, no group differences in the amount of interindividual variability of DTI and NODDI metrics were observed. We conclude that microstructural detriment in the reconstructed fiber bundles along with developmental and morphological differences are likely to contribute to disadvantages in AVI in preterm individuals. |
| first_indexed | 2024-04-09T17:13:32Z |
| format | Article |
| id | doaj.art-2c39118f201d462a9953d4f6fee2c6ce |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-04-09T17:13:32Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-2c39118f201d462a9953d4f6fee2c6ce2023-04-20T04:36:04ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-04-0160101202Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regionsJuan F. Quinones0Andrea Hildebrandt1Tommaso Pavan2Christiane M. Thiel3Axel Heep4Psychological Methods and Statistics, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; Cluster of Excellence Hearing4all, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; Correspondence to: Carl von Ossietzky Universität Oldenburg, Department of Psychology, Ammerländer Heerstr., 114-11, 826129 Oldenburg, Germany.Psychological Methods and Statistics, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; Cluster of Excellence Hearing4all, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Germany; Correspondence to: Carl von Ossietzky Universität Oldenburg, Department of Psychology, Ammerländer Heerstr., 114-11, 826129 Oldenburg, Germany.Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandCluster of Excellence Hearing4all, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Germany; Biological Psychology, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, GermanyResearch Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Germany; Klinik für Neonatologie, Intensivmedizin und Kinderkardiologie, Oldenburg, GermanyIndividuals born preterm are at risk of developing a variety of sequelae. Audiovisual integration (AVI) has received little attention despite its facilitating role in the development of socio-cognitive abilities. The present study assessed the association between prematurity and in-vivo reconstructed fiber bundles among brain regions relevant for AVI. We retrieved data from 63 preterm neonates enrolled in the Developing Human Connectome Project (http://www.developingconnectome.org/) and matched them with 63 term-born neonates from the same study by means of propensity score matching. We performed probabilistic tractography, DTI and NODDI analysis on the traced fibers. We found that specific DTI and NODDI metrics are significantly associated with prematurity in neonates matched for postmenstrual age at scan. We investigated the spatial overlap and developmental order of the reconstructed tractograms between preterm and full-term neonates. Permutation-based analysis revealed significant differences in dice similarity coefficients and developmental order between preterm and full term neonates at the group level. Contrarily, no group differences in the amount of interindividual variability of DTI and NODDI metrics were observed. We conclude that microstructural detriment in the reconstructed fiber bundles along with developmental and morphological differences are likely to contribute to disadvantages in AVI in preterm individuals.http://www.sciencedirect.com/science/article/pii/S1878929323000075Audiovisual integrationNeonatesPretermStructural connectivityDTINODDI |
| spellingShingle | Juan F. Quinones Andrea Hildebrandt Tommaso Pavan Christiane M. Thiel Axel Heep Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regions Developmental Cognitive Neuroscience Audiovisual integration Neonates Preterm Structural connectivity DTI NODDI |
| title | Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regions |
| title_full | Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regions |
| title_fullStr | Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regions |
| title_full_unstemmed | Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regions |
| title_short | Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regions |
| title_sort | preterm birth and neonatal white matter microstructure in in vivo reconstructed fiber tracts among audiovisual integration brain regions |
| topic | Audiovisual integration Neonates Preterm Structural connectivity DTI NODDI |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323000075 |
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