Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis
Abstract Objective To verify the clinical efficacy of Zhang’s Xibi formula (ZSXBF) and explain the mechanism underlying its therapeutic effect. Methods Preliminary elucidation of the clinical efficacy of ZSXBF in treating KOA in self-control studies, exploration of its mechanism of action with netwo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-04453-6 |
| _version_ | 1827581487347662848 |
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| author | Qi Sun Hongting Jin Wuyin Li Peijian Tong Wenhua Yuan |
| author_facet | Qi Sun Hongting Jin Wuyin Li Peijian Tong Wenhua Yuan |
| author_sort | Qi Sun |
| collection | DOAJ |
| description | Abstract Objective To verify the clinical efficacy of Zhang’s Xibi formula (ZSXBF) and explain the mechanism underlying its therapeutic effect. Methods Preliminary elucidation of the clinical efficacy of ZSXBF in treating KOA in self-control studies, exploration of its mechanism of action with network pharmacology methods, and validation in animal experiments. Results In clinical studies, ZSXBF administration effectively improved patient quality of life and reduce pain. Network pharmacology was used to explore the possible mechanisms underlying its treatment effect, and after verification in clinical experience and animal experiments, it was found that ZSXBF regulated the expression of immune-related proteins such as IL-17, ERK1, and TP53 in mouse knee joints. Conclusion ZSXBF, which is a traditional Chinese medicine compound that is used to clear heat and detoxify, can effectively improve the clinical symptoms of KOA patients, and its underlying mechanism includes the regulation of human immune-related proteins. |
| first_indexed | 2024-03-08T22:36:11Z |
| format | Article |
| id | doaj.art-2c395512cbff49588ba0f966b7377584 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-08T22:36:11Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-2c395512cbff49588ba0f966b73775842023-12-17T12:24:48ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-12-011811910.1186/s13018-023-04453-6Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritisQi Sun0Hongting Jin1Wuyin Li2Peijian Tong3Wenhua Yuan4Institute of Orthopedics and Traumatology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang Chinese Medical UniversityInstitute of Orthopedics and Traumatology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang Chinese Medical UniversityDepartment of Orthopedic, Luoyang Orthopedic Hospital of Henan ProvinceInstitute of Orthopedics and Traumatology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang Chinese Medical UniversityInstitute of Orthopedics and Traumatology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang Chinese Medical UniversityAbstract Objective To verify the clinical efficacy of Zhang’s Xibi formula (ZSXBF) and explain the mechanism underlying its therapeutic effect. Methods Preliminary elucidation of the clinical efficacy of ZSXBF in treating KOA in self-control studies, exploration of its mechanism of action with network pharmacology methods, and validation in animal experiments. Results In clinical studies, ZSXBF administration effectively improved patient quality of life and reduce pain. Network pharmacology was used to explore the possible mechanisms underlying its treatment effect, and after verification in clinical experience and animal experiments, it was found that ZSXBF regulated the expression of immune-related proteins such as IL-17, ERK1, and TP53 in mouse knee joints. Conclusion ZSXBF, which is a traditional Chinese medicine compound that is used to clear heat and detoxify, can effectively improve the clinical symptoms of KOA patients, and its underlying mechanism includes the regulation of human immune-related proteins.https://doi.org/10.1186/s13018-023-04453-6Knee osteoarthritisZhang’s Xibi formulaImmunityNetwork pharmacology |
| spellingShingle | Qi Sun Hongting Jin Wuyin Li Peijian Tong Wenhua Yuan Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis Journal of Orthopaedic Surgery and Research Knee osteoarthritis Zhang’s Xibi formula Immunity Network pharmacology |
| title | Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis |
| title_full | Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis |
| title_fullStr | Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis |
| title_full_unstemmed | Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis |
| title_short | Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis |
| title_sort | study of the curative effect of zhang s xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis |
| topic | Knee osteoarthritis Zhang’s Xibi formula Immunity Network pharmacology |
| url | https://doi.org/10.1186/s13018-023-04453-6 |
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