Clinical Evaluation of Non-functional Invasive Hypophysis Adenomas
Background: There are ongoing studies to predetermine non-functional invasive pituitary adenomas that may show aggressive behavior. Our aim is to discuss whether there is a relationship between the immunohistochemical presence of GH, FSH, LH, PRL, ACTH, TSH and their aggressive clinical course in no...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2020-06-01
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| Series: | Sudan Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/sjms.v15i2.5027 |
| _version_ | 1818359125306769408 |
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| author | Feyzi Gokosmanoglu Ceyhun Varim Kenan Evren Oztop |
| author_facet | Feyzi Gokosmanoglu Ceyhun Varim Kenan Evren Oztop |
| author_sort | Feyzi Gokosmanoglu |
| collection | DOAJ |
| description | Background: There are ongoing studies to predetermine non-functional invasive pituitary adenomas that may show aggressive behavior. Our aim is to discuss whether there is a relationship between the immunohistochemical presence of GH, FSH, LH, PRL, ACTH, TSH and their aggressive clinical course in non-functional pituitary adenomas.
Materials and Methods:
In this study, we evaluated retrospectively the files of the patients who were diagnosed with the sellar or parasellar tumor in our endocrinology clinic between the years of 2004 and 2014. The patients were divided into two groups as non-invasive pituitary adenomas and non-functional invasive pituitary adenomas. The immunohistochemical staining characteristics were compared between the two groups.
Results:
In this study, we scanned the data of 70 patients who were followed for non-functional sellar or parasellar mass; 47.1% of the patients were female and 52.9% were male. Of them, 39 patients had a non-functional pituitary adenoma whereas 20.5% of them had non-functional invasive adenoma. While there was a significant relationship between the immunohistochemical positivity of GH, FSH, LH and the aggressive behavior of non-functional invasive adenomas. no significant relationship was found between the immunohistochemical positivity of PRL, ACTH, TSH and the aggressive behavior of non-functional invasive adenomas.
Conclusion:
We found silent GH and gonadotropin adenomas as non-functional aggressive pituitary adenoma. More aggressive treatment and close clinical monitoring should be performed because atypical pituitary adenomas are characterized by invasive growth and aggressive clinical course. |
| first_indexed | 2024-12-13T20:39:55Z |
| format | Article |
| id | doaj.art-2c3d384af12f4ea19f6a67d340d8ab05 |
| institution | Directory Open Access Journal |
| issn | 1858-5051 |
| language | English |
| last_indexed | 2024-12-13T20:39:55Z |
| publishDate | 2020-06-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj.art-2c3d384af12f4ea19f6a67d340d8ab052022-12-21T23:32:11ZengKnowledge ESudan Journal of Medical Sciences1858-50512020-06-011510.18502/sjms.v15i2.5027sjms.v15i2.5027Clinical Evaluation of Non-functional Invasive Hypophysis AdenomasFeyzi Gokosmanoglu0Ceyhun Varim1Kenan Evren Oztop2 Department of Internal Medicine, Konak Hospital, Sakarya, Turkey Department of Internal Medicine, Konak Hospital, Sakarya, Turkey Department of Internal Medicine, Konak Hospital, Sakarya, TurkeyBackground: There are ongoing studies to predetermine non-functional invasive pituitary adenomas that may show aggressive behavior. Our aim is to discuss whether there is a relationship between the immunohistochemical presence of GH, FSH, LH, PRL, ACTH, TSH and their aggressive clinical course in non-functional pituitary adenomas. Materials and Methods: In this study, we evaluated retrospectively the files of the patients who were diagnosed with the sellar or parasellar tumor in our endocrinology clinic between the years of 2004 and 2014. The patients were divided into two groups as non-invasive pituitary adenomas and non-functional invasive pituitary adenomas. The immunohistochemical staining characteristics were compared between the two groups. Results: In this study, we scanned the data of 70 patients who were followed for non-functional sellar or parasellar mass; 47.1% of the patients were female and 52.9% were male. Of them, 39 patients had a non-functional pituitary adenoma whereas 20.5% of them had non-functional invasive adenoma. While there was a significant relationship between the immunohistochemical positivity of GH, FSH, LH and the aggressive behavior of non-functional invasive adenomas. no significant relationship was found between the immunohistochemical positivity of PRL, ACTH, TSH and the aggressive behavior of non-functional invasive adenomas. Conclusion: We found silent GH and gonadotropin adenomas as non-functional aggressive pituitary adenoma. More aggressive treatment and close clinical monitoring should be performed because atypical pituitary adenomas are characterized by invasive growth and aggressive clinical course.https://doi.org/10.18502/sjms.v15i2.5027pituitary adenoma, non-functional, invasive |
| spellingShingle | Feyzi Gokosmanoglu Ceyhun Varim Kenan Evren Oztop Clinical Evaluation of Non-functional Invasive Hypophysis Adenomas Sudan Journal of Medical Sciences pituitary adenoma, non-functional, invasive |
| title | Clinical Evaluation of Non-functional Invasive Hypophysis Adenomas |
| title_full | Clinical Evaluation of Non-functional Invasive Hypophysis Adenomas |
| title_fullStr | Clinical Evaluation of Non-functional Invasive Hypophysis Adenomas |
| title_full_unstemmed | Clinical Evaluation of Non-functional Invasive Hypophysis Adenomas |
| title_short | Clinical Evaluation of Non-functional Invasive Hypophysis Adenomas |
| title_sort | clinical evaluation of non functional invasive hypophysis adenomas |
| topic | pituitary adenoma, non-functional, invasive |
| url | https://doi.org/10.18502/sjms.v15i2.5027 |
| work_keys_str_mv | AT feyzigokosmanoglu clinicalevaluationofnonfunctionalinvasivehypophysisadenomas AT ceyhunvarim clinicalevaluationofnonfunctionalinvasivehypophysisadenomas AT kenanevrenoztop clinicalevaluationofnonfunctionalinvasivehypophysisadenomas |