Arterial klotho expression and FGF23 effects on vascular calcification and function.
Recent studies support a role for FGF23 and its co-receptor Klotho in cardiovascular pathology, yet the underlying mechanisms remain largely elusive. Herein, we analyzed the expression of Klotho in mouse arteries and generated a novel mouse model harboring a vascular smooth muscle cell specific dele...
Main Authors: | Karolina Lindberg, Hannes Olauson, Risul Amin, Arvind Ponnusamy, Regina Goetz, Rebecca F Taylor, Moosa Mohammadi, Ann Canfield, Karolina Kublickiene, Tobias E Larsson |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3618102?pdf=render |
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