Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis
Background and Purpose: The eosinophil-to-neutrophil ratio (ENR) was recently reported as a novel inflammatory marker in acute ischemic stroke (AIS). However, few studies reported the predictive value of ENR in AIS patients, especially for those with intravenous thrombolysis.Methods: Two hundred six...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.665827/full |
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| author | Haoye Cai Honghao Huang Honghao Huang Chenguang Yang Chenguang Yang Junli Ren Junli Ren Jianing Wang Jianing Wang Beibei Gao Wenjing Pan Wenjing Pan Fangyue Sun Fangyue Sun Xinbo Zhou Xinbo Zhou Tian Zeng Tian Zeng Jingyu Hu Jingyu Hu Yilin Chen Yilin Chen Shunkai Zhang Guangyong Chen |
| author_facet | Haoye Cai Honghao Huang Honghao Huang Chenguang Yang Chenguang Yang Junli Ren Junli Ren Jianing Wang Jianing Wang Beibei Gao Wenjing Pan Wenjing Pan Fangyue Sun Fangyue Sun Xinbo Zhou Xinbo Zhou Tian Zeng Tian Zeng Jingyu Hu Jingyu Hu Yilin Chen Yilin Chen Shunkai Zhang Guangyong Chen |
| author_sort | Haoye Cai |
| collection | DOAJ |
| description | Background and Purpose: The eosinophil-to-neutrophil ratio (ENR) was recently reported as a novel inflammatory marker in acute ischemic stroke (AIS). However, few studies reported the predictive value of ENR in AIS patients, especially for those with intravenous thrombolysis.Methods: Two hundred sixty-six AIS patients receiving intravenous thrombolysis were retrospectively recruited in this study and followed up for 3 months and 1 year. The Modified Rankin Scale (mRS) and the time of death were recorded. Poor outcome was defined as mRS 3–6. After excluding patients who were lost to follow-up, the remaining 250 patients were included in the 3-month prognosis analysis and the remaining 223 patients were included in the 1-year prognosis analysis.Results: ENR levels in the patients were lower than those in the healthy controls. The optimal cutoff values for the ability of ENR × 102 to predict 3-month poor outcome were 0.74 with 67.8% sensitivity and 77.3% specificity. Patients with ENR × 102 ≥ 0.74 have a lower baseline National Institutes of Health Stroke Scale (NIHSS) score (median: 7 vs. 11, p < 0.001). After multivariate adjustment, patients with ENR × 102 ≥ 0.74 were more likely to come to a better 3-month outcome (OR = 0.163; 95% CI, 0.076–0.348, p < 0.001). At the 1-year follow-up, the patients with ENR × 102 ≥ 0.74 showed a lower risk of mortality (HR = 0.314; 95% CI, 0.135–0.731; p = 0.007).Conclusions: A lower ENR is independently associated with a 3-month poor outcome and a 3-month and 1-year mortality in AIS patients treated with intravenous thrombolysis. |
| first_indexed | 2024-12-17T00:12:23Z |
| format | Article |
| id | doaj.art-2c4180e75eea485883b0bd3ce798a5a7 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-17T00:12:23Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-2c4180e75eea485883b0bd3ce798a5a72022-12-21T22:10:47ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-07-011210.3389/fneur.2021.665827665827Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous ThrombolysisHaoye Cai0Honghao Huang1Honghao Huang2Chenguang Yang3Chenguang Yang4Junli Ren5Junli Ren6Jianing Wang7Jianing Wang8Beibei Gao9Wenjing Pan10Wenjing Pan11Fangyue Sun12Fangyue Sun13Xinbo Zhou14Xinbo Zhou15Tian Zeng16Tian Zeng17Jingyu Hu18Jingyu Hu19Yilin Chen20Yilin Chen21Shunkai Zhang22Guangyong Chen23Department of Rehabilitation Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Internal Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaBackground and Purpose: The eosinophil-to-neutrophil ratio (ENR) was recently reported as a novel inflammatory marker in acute ischemic stroke (AIS). However, few studies reported the predictive value of ENR in AIS patients, especially for those with intravenous thrombolysis.Methods: Two hundred sixty-six AIS patients receiving intravenous thrombolysis were retrospectively recruited in this study and followed up for 3 months and 1 year. The Modified Rankin Scale (mRS) and the time of death were recorded. Poor outcome was defined as mRS 3–6. After excluding patients who were lost to follow-up, the remaining 250 patients were included in the 3-month prognosis analysis and the remaining 223 patients were included in the 1-year prognosis analysis.Results: ENR levels in the patients were lower than those in the healthy controls. The optimal cutoff values for the ability of ENR × 102 to predict 3-month poor outcome were 0.74 with 67.8% sensitivity and 77.3% specificity. Patients with ENR × 102 ≥ 0.74 have a lower baseline National Institutes of Health Stroke Scale (NIHSS) score (median: 7 vs. 11, p < 0.001). After multivariate adjustment, patients with ENR × 102 ≥ 0.74 were more likely to come to a better 3-month outcome (OR = 0.163; 95% CI, 0.076–0.348, p < 0.001). At the 1-year follow-up, the patients with ENR × 102 ≥ 0.74 showed a lower risk of mortality (HR = 0.314; 95% CI, 0.135–0.731; p = 0.007).Conclusions: A lower ENR is independently associated with a 3-month poor outcome and a 3-month and 1-year mortality in AIS patients treated with intravenous thrombolysis.https://www.frontiersin.org/articles/10.3389/fneur.2021.665827/fullischemic strokeinflammationprognosisthrombolysiseosinophil-to-neutrophil ratio |
| spellingShingle | Haoye Cai Honghao Huang Honghao Huang Chenguang Yang Chenguang Yang Junli Ren Junli Ren Jianing Wang Jianing Wang Beibei Gao Wenjing Pan Wenjing Pan Fangyue Sun Fangyue Sun Xinbo Zhou Xinbo Zhou Tian Zeng Tian Zeng Jingyu Hu Jingyu Hu Yilin Chen Yilin Chen Shunkai Zhang Guangyong Chen Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis Frontiers in Neurology ischemic stroke inflammation prognosis thrombolysis eosinophil-to-neutrophil ratio |
| title | Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis |
| title_full | Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis |
| title_fullStr | Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis |
| title_full_unstemmed | Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis |
| title_short | Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis |
| title_sort | eosinophil to neutrophil ratio predicts poor prognosis of acute ischemic stroke patients treated with intravenous thrombolysis |
| topic | ischemic stroke inflammation prognosis thrombolysis eosinophil-to-neutrophil ratio |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.665827/full |
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