l-Citrulline improves cerebral blood flow in migraine model rats
We have previously reported that intravenous injection of l-citrulline, an α-amino acid isolated from watermelon juice, prevented the decrease in cerebral blood flow (CBF) during cortical spreading depression (CSD) in rats, a widely accepted animal model of migraine aura. However it is not clear whe...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-11-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617305789 |
| _version_ | 1818415655764885504 |
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| author | Yuki Kurauchi Koichi Mokudai Masahiko Morita Ayako Kamimura Asami Mori Kenji Sakamoto Tsutomu Nakahara Kunio Ishii |
| author_facet | Yuki Kurauchi Koichi Mokudai Masahiko Morita Ayako Kamimura Asami Mori Kenji Sakamoto Tsutomu Nakahara Kunio Ishii |
| author_sort | Yuki Kurauchi |
| collection | DOAJ |
| description | We have previously reported that intravenous injection of l-citrulline, an α-amino acid isolated from watermelon juice, prevented the decrease in cerebral blood flow (CBF) during cortical spreading depression (CSD) in rats, a widely accepted animal model of migraine aura. However it is not clear whether oral l-citrulline administration improves CBF during CSD or not. For clinical application of l-citrulline against migraine aura, we evaluated the effect of oral l-citrulline administration on the parameters of CSD. Daily oral administration of l-citrulline for 8 consecutive days increased brain concentration of l-arginine as well as l-citrulline. Moreover, l-citrulline reduced the disturbance of CBF, monitored by laser Doppler flowmetry, with less effect on mean arterial pressure and heart rate during CSD. Although l-citrulline had no effect on CSD propagation velocity, it accelerated the recovery of CBF changes. These results suggest that l-citrulline has a clinically beneficial effect on migraine aura via regulation of CBF. |
| first_indexed | 2024-12-14T11:38:27Z |
| format | Article |
| id | doaj.art-2c42e591d7d54401a195223454bc2053 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T11:38:27Z |
| publishDate | 2017-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-2c42e591d7d54401a195223454bc20532022-12-21T23:02:54ZengElsevierJournal of Functional Foods1756-46462017-11-0138540544l-Citrulline improves cerebral blood flow in migraine model ratsYuki Kurauchi0Koichi Mokudai1Masahiko Morita2Ayako Kamimura3Asami Mori4Kenji Sakamoto5Tsutomu Nakahara6Kunio Ishii7Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan; Corresponding author at: Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, JapanHealthcare Products Development Center, KYOWA HAKKO BIO CO., Ltd., 2 Miyukigaoka, Tsukuba-shi, Ibaraki 305-0841, JapanHealthcare Products Development Center, KYOWA HAKKO BIO CO., Ltd., 2 Miyukigaoka, Tsukuba-shi, Ibaraki 305-0841, JapanDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, JapanDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, JapanDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, JapanDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan1We have previously reported that intravenous injection of l-citrulline, an α-amino acid isolated from watermelon juice, prevented the decrease in cerebral blood flow (CBF) during cortical spreading depression (CSD) in rats, a widely accepted animal model of migraine aura. However it is not clear whether oral l-citrulline administration improves CBF during CSD or not. For clinical application of l-citrulline against migraine aura, we evaluated the effect of oral l-citrulline administration on the parameters of CSD. Daily oral administration of l-citrulline for 8 consecutive days increased brain concentration of l-arginine as well as l-citrulline. Moreover, l-citrulline reduced the disturbance of CBF, monitored by laser Doppler flowmetry, with less effect on mean arterial pressure and heart rate during CSD. Although l-citrulline had no effect on CSD propagation velocity, it accelerated the recovery of CBF changes. These results suggest that l-citrulline has a clinically beneficial effect on migraine aura via regulation of CBF.http://www.sciencedirect.com/science/article/pii/S1756464617305789l-arginineCerebral blood flowCerebrovascular disorderl-citrullineCortical spreading depressionMigraine |
| spellingShingle | Yuki Kurauchi Koichi Mokudai Masahiko Morita Ayako Kamimura Asami Mori Kenji Sakamoto Tsutomu Nakahara Kunio Ishii l-Citrulline improves cerebral blood flow in migraine model rats Journal of Functional Foods l-arginine Cerebral blood flow Cerebrovascular disorder l-citrulline Cortical spreading depression Migraine |
| title | l-Citrulline improves cerebral blood flow in migraine model rats |
| title_full | l-Citrulline improves cerebral blood flow in migraine model rats |
| title_fullStr | l-Citrulline improves cerebral blood flow in migraine model rats |
| title_full_unstemmed | l-Citrulline improves cerebral blood flow in migraine model rats |
| title_short | l-Citrulline improves cerebral blood flow in migraine model rats |
| title_sort | l citrulline improves cerebral blood flow in migraine model rats |
| topic | l-arginine Cerebral blood flow Cerebrovascular disorder l-citrulline Cortical spreading depression Migraine |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617305789 |
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