Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice
Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00467/full |
| _version_ | 1819134964775518208 |
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| author | Francesco Colucci Francesco Colucci Louise M. Gaynor Louise M. Gaynor |
| author_facet | Francesco Colucci Francesco Colucci Louise M. Gaynor Louise M. Gaynor |
| author_sort | Francesco Colucci |
| collection | DOAJ |
| description | Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy. |
| first_indexed | 2024-12-22T10:11:33Z |
| format | Article |
| id | doaj.art-2c434ed385244f369419033d49e75582 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T10:11:33Z |
| publishDate | 2017-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2c434ed385244f369419033d49e755822022-12-21T18:29:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-04-01810.3389/fimmu.2017.00467257756Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and MiceFrancesco Colucci0Francesco Colucci1Louise M. Gaynor2Louise M. Gaynor3Centre for Trophoblast Research, University of Cambridge, Cambridge, UKDepartment of Obstetrics and Gynaecology, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge School of Clinical Medicine, Cambridge, UKCentre for Trophoblast Research, University of Cambridge, Cambridge, UKDepartment of Obstetrics and Gynaecology, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge School of Clinical Medicine, Cambridge, UKOur understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00467/fulluterine natural killer cellsuterine innate lymphoid cellsplacentapregnancyarterial remodelingtrophoblast |
| spellingShingle | Francesco Colucci Francesco Colucci Louise M. Gaynor Louise M. Gaynor Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice Frontiers in Immunology uterine natural killer cells uterine innate lymphoid cells placenta pregnancy arterial remodeling trophoblast |
| title | Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice |
| title_full | Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice |
| title_fullStr | Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice |
| title_full_unstemmed | Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice |
| title_short | Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice |
| title_sort | uterine natural killer cells functional distinctions and influence on pregnancy in humans and mice |
| topic | uterine natural killer cells uterine innate lymphoid cells placenta pregnancy arterial remodeling trophoblast |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00467/full |
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