Normative ranges of biventricular volumes and function in healthy term newborns
Abstract Background Cardiovascular magnetic resonance (CMR) is increasingly used in newborns with congenital heart disease. However, reporting on ventricular volumes and mass is hindered by an absence of normative data in this population. Design/methods Healthy term (37–41 weeks gestation) newborns...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12968-023-00932-1 |
| _version_ | 1797836402490081280 |
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| author | Simone Jhaveri Ellie Battersby Kenan W. D. Stern Jennifer Cohen Yang Yang Anthony Price Emer Hughes Lucilla Poston Dharmintra Pasupathy Paul Taylor Matias C. Vieira Alan Groves |
| author_facet | Simone Jhaveri Ellie Battersby Kenan W. D. Stern Jennifer Cohen Yang Yang Anthony Price Emer Hughes Lucilla Poston Dharmintra Pasupathy Paul Taylor Matias C. Vieira Alan Groves |
| author_sort | Simone Jhaveri |
| collection | DOAJ |
| description | Abstract Background Cardiovascular magnetic resonance (CMR) is increasingly used in newborns with congenital heart disease. However, reporting on ventricular volumes and mass is hindered by an absence of normative data in this population. Design/methods Healthy term (37–41 weeks gestation) newborns underwent non-sedated, free-breathing CMR within the first week of life using the ‘feed and wrap’ technique. End-diastolic volume (EDV), end-systolic volume (ESV) stroke volume (SV) and ejection fraction (EF) were calculated for both left ventricle (LV) and right ventricle (RV). Papillary muscles were separately contoured and included in the myocardial volume. Myocardial mass was calculated by multiplying myocardial volume by 1.05 g/ml. All data were indexed to weight and body surface area (BSA). Inter-observer variability (IOV) was performed on data from 10 randomly chosen infants. Results Twenty healthy newborns (65% male) with a mean (SD) birth weight of 3.54 (0.46) kg and BSA of 0.23 (0.02) m2 were included. Normative LV parameters were indexed EDV 39.0 (4.1) ml/m2, ESV 14.5 (2.5) ml/m2 and ejection fraction (EF) 63.2 (3.4)%. Normative RV indexed EDV, ESV and EF were 47.4 (4.5) ml/m2, 22.6 (2.9) ml/m2 and 52.5 (3.3)% respectively. Mean LV and RV indexed mass were 26.4 (2.8) g/m2 and 12.5 (2.0) g/m2, respectively. There was no difference in ventricular volumes by gender. IOV was excellent with an intra-class coefficient > 0.95 except for RV mass (0.94). Conclusion This study provides normative data on LV and RV parameters in healthy newborns, providing a novel resource for comparison with newborns with structural and functional heart disease. |
| first_indexed | 2024-04-09T15:08:15Z |
| format | Article |
| id | doaj.art-2c445a404a4646e9b9c4d98f3cea9c3c |
| institution | Directory Open Access Journal |
| issn | 1532-429X |
| language | English |
| last_indexed | 2024-04-09T15:08:15Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-2c445a404a4646e9b9c4d98f3cea9c3c2023-04-30T11:19:38ZengBMCJournal of Cardiovascular Magnetic Resonance1532-429X2023-04-012511810.1186/s12968-023-00932-1Normative ranges of biventricular volumes and function in healthy term newbornsSimone Jhaveri0Ellie Battersby1Kenan W. D. Stern2Jennifer Cohen3Yang Yang4Anthony Price5Emer Hughes6Lucilla Poston7Dharmintra Pasupathy8Paul Taylor9Matias C. Vieira10Alan Groves11Department of Pediatric Cardiology, Icahn School of Medicine at Mount SinaiCenter for the Developing Brain, Kings College LondonDepartment of Pediatric Cardiology, Icahn School of Medicine at Mount SinaiDepartment of Pediatric Cardiology, Icahn School of Medicine at Mount SinaiBiomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount SinaiCenter for the Developing Brain, Kings College LondonCenter for the Developing Brain, Kings College LondonDepartment of Women and Children’s Health, School of Life Course and Population Sciences, Kings College LondonDepartment of Women and Children’s Health, School of Life Course and Population Sciences, Kings College LondonDepartment of Women and Children’s Health, School of Life Course and Population Sciences, Kings College LondonDepartment of Women and Children’s Health, School of Life Course and Population Sciences, Kings College LondonDepartment of Pediatrics, Dell Medical School at the University of AustinAbstract Background Cardiovascular magnetic resonance (CMR) is increasingly used in newborns with congenital heart disease. However, reporting on ventricular volumes and mass is hindered by an absence of normative data in this population. Design/methods Healthy term (37–41 weeks gestation) newborns underwent non-sedated, free-breathing CMR within the first week of life using the ‘feed and wrap’ technique. End-diastolic volume (EDV), end-systolic volume (ESV) stroke volume (SV) and ejection fraction (EF) were calculated for both left ventricle (LV) and right ventricle (RV). Papillary muscles were separately contoured and included in the myocardial volume. Myocardial mass was calculated by multiplying myocardial volume by 1.05 g/ml. All data were indexed to weight and body surface area (BSA). Inter-observer variability (IOV) was performed on data from 10 randomly chosen infants. Results Twenty healthy newborns (65% male) with a mean (SD) birth weight of 3.54 (0.46) kg and BSA of 0.23 (0.02) m2 were included. Normative LV parameters were indexed EDV 39.0 (4.1) ml/m2, ESV 14.5 (2.5) ml/m2 and ejection fraction (EF) 63.2 (3.4)%. Normative RV indexed EDV, ESV and EF were 47.4 (4.5) ml/m2, 22.6 (2.9) ml/m2 and 52.5 (3.3)% respectively. Mean LV and RV indexed mass were 26.4 (2.8) g/m2 and 12.5 (2.0) g/m2, respectively. There was no difference in ventricular volumes by gender. IOV was excellent with an intra-class coefficient > 0.95 except for RV mass (0.94). Conclusion This study provides normative data on LV and RV parameters in healthy newborns, providing a novel resource for comparison with newborns with structural and functional heart disease.https://doi.org/10.1186/s12968-023-00932-1NeonatesCardiovascular magnetic resonance imagingNormative dataLeft ventricular volumeLeft ventricular massRight ventricular volume |
| spellingShingle | Simone Jhaveri Ellie Battersby Kenan W. D. Stern Jennifer Cohen Yang Yang Anthony Price Emer Hughes Lucilla Poston Dharmintra Pasupathy Paul Taylor Matias C. Vieira Alan Groves Normative ranges of biventricular volumes and function in healthy term newborns Journal of Cardiovascular Magnetic Resonance Neonates Cardiovascular magnetic resonance imaging Normative data Left ventricular volume Left ventricular mass Right ventricular volume |
| title | Normative ranges of biventricular volumes and function in healthy term newborns |
| title_full | Normative ranges of biventricular volumes and function in healthy term newborns |
| title_fullStr | Normative ranges of biventricular volumes and function in healthy term newborns |
| title_full_unstemmed | Normative ranges of biventricular volumes and function in healthy term newborns |
| title_short | Normative ranges of biventricular volumes and function in healthy term newborns |
| title_sort | normative ranges of biventricular volumes and function in healthy term newborns |
| topic | Neonates Cardiovascular magnetic resonance imaging Normative data Left ventricular volume Left ventricular mass Right ventricular volume |
| url | https://doi.org/10.1186/s12968-023-00932-1 |
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