Protective Effect of Tempol on Acute Kidney Injury Through PI3K/Akt/Nrf2 Signaling Pathway

Protective Effect of Tempol on Acute Kidney Injury Through PI3K/Akt/Nrf2 Signaling Pathway

Background/Aims: Tempol is a protective antioxidant against ischemic injury in many animal models. The molecular mechanisms are not well understood. Nuclear factor erythroid 2-related factor (Nrf2) is a master transcription factor during oxidative stress, which is enhanced by activation of protein k...

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Bibliographic Details
Main Authors: Gensheng Zhang, Qiaoling Wang, Qin Zhou, Renjun Wang, Minze Xu, Huiping Wang, Lei Wang, Christopher S. Wilcox, Ruisheng Liu, En Yin Lai
Format: Article
Language:English
Published: Karger Publishers 2016-02-01
Series:Kidney & Blood Pressure Research
Subjects:
Ischemia reperfusion
Tempol
Nrf2
Acute kidney injury
Online Access:http://www.karger.com/Article/FullText/443414

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