Estimation of Salivary Parameters among Autoimmune Thyroiditis Patients
Introduction: Saliva is a complex secretion that protects and lubricates the oral cavity. Various systemic diseases and their treatment alter the salivary gland function; one such disease is Autoimmune Thyroid Disease (AITD). AITD has been postulated to exert its hormonal influence on the saliva...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10128/26444_CE(RA1)_F(T)_PF1(PrG)_PFA(P_PrG).pdf |
| Summary: | Introduction: Saliva is a complex secretion that protects and
lubricates the oral cavity. Various systemic diseases and their
treatment alter the salivary gland function; one such disease is
Autoimmune Thyroid Disease (AITD). AITD has been postulated
to exert its hormonal influence on the salivary glands, leading to
reduced salivary output. There’s a paucity of literature, verifying
the stated conjunction in human subjects.
Aim: The aim was to investigate the salivary profile in AITD patients and its comparison with controls.
Materials and Methods: Descriptive cross-sectional comparative study was conducted using convenience sampling
method for screening the presence of thyroid disorders. Two
groups comprising of 30 patients in each group diagnosed with
autoimmune hypothyroiditis (n=30) and hyperthyroiditis (n=30)
respectively and thirty healthy volunteers who were age and sex
matched were included as controls. Saliva was collected and
evaluated for Unstimulated Salivary Flow Rate (USSFR), pH and
buffer capacity. ANOVA and Tukey post-hoc test was performed
to find the statistical significance and for pairwise comparison.
Results:Statistically significant difference was observed between
autoimmune hypothyroiditis, autoimmune hyperthyroiditis and
control group with respect to USSFR (p<0.007), pH (p<0.001)
and buffer capacity (p<0.001). On pairwise comparisons
statistically significant difference was observed between
autoimmune hypothyroiditis and autoimmune hyperthyroiditis
with respect to controls.
Conclusion: We conclude that significant involvement of
salivary glands may occur in cases of AITD. Our study showed
significant reduction of sialometric values in AITD patients
when compared to controls. A strong clinical suspicion of
thyroid diseases should be considered when there is chronic
hyposalivation; hence thyroid profile must also be done, if the
known causes have been excluded. |
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| ISSN: | 2249-782X 0973-709X |