Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats
Background: The whole plant of Coccinia indica is very effective in different types of diseases with fewer side effects. The leaves, roots of this plant were claimed to be useful in the treatment of diabetes mellitus based on folk medicine. The purpose of this study was to examine the antihyperglyce...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2019-07-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/24180 |
| _version_ | 1818312796879716352 |
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| author | Mamata Pochhi |
| author_facet | Mamata Pochhi |
| author_sort | Mamata Pochhi |
| collection | DOAJ |
| description | Background: The whole plant of Coccinia indica is very effective in different types of diseases with fewer side effects. The leaves, roots of this plant were claimed to be useful in the treatment of diabetes mellitus based on folk medicine. The purpose of this study was to examine the antihyperglycemic effect of water extract of C. indica in alloxan diabetes rats.
Aims and Objectives: The aim of this study is to find whether the conditions, hyperglyclemia and hyerlipidemia, are correlated and whether the application of the aqueous extract leads to abating these two conditions.
Materials-Methods: The aqueous leaves extracts of C. indica (200 mg/kg) were administered orally for 14 days, in alloxan induced diabetic rats on Glucose, Lipid profile, Lipoproteins and Lipid metabolizing enzymes activity.
Result: The aqueous leaves extract of C. indica induced significant improvement in glucose, serum Lipids, lipoproteins and lipid metabolizing enzyme activity (HMG CoA reductase, LCAT).
Conclusion: The present study indicates that the extract of Coccinia indica exhibits lipid lowering, maintaining lipoproteins concentration and also improves the activities of lipid metabolizing enzyme in hyperglycemic rats leading to an increase in peripheral glucose consumption. |
| first_indexed | 2024-12-13T08:23:33Z |
| format | Article |
| id | doaj.art-2c489766e6894a24b630f43940eeee64 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-13T08:23:33Z |
| publishDate | 2019-07-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-2c489766e6894a24b630f43940eeee642022-12-21T23:53:56ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762019-07-011044954https://doi.org/10.3126/ajms.v10i4.24180Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino ratsMamata Pochhi 0Shree Shankaracharya Institute of Medical Science, Bhilai, India https://orcid.org/0000-0002-8555-1316Background: The whole plant of Coccinia indica is very effective in different types of diseases with fewer side effects. The leaves, roots of this plant were claimed to be useful in the treatment of diabetes mellitus based on folk medicine. The purpose of this study was to examine the antihyperglycemic effect of water extract of C. indica in alloxan diabetes rats. Aims and Objectives: The aim of this study is to find whether the conditions, hyperglyclemia and hyerlipidemia, are correlated and whether the application of the aqueous extract leads to abating these two conditions. Materials-Methods: The aqueous leaves extracts of C. indica (200 mg/kg) were administered orally for 14 days, in alloxan induced diabetic rats on Glucose, Lipid profile, Lipoproteins and Lipid metabolizing enzymes activity. Result: The aqueous leaves extract of C. indica induced significant improvement in glucose, serum Lipids, lipoproteins and lipid metabolizing enzyme activity (HMG CoA reductase, LCAT). Conclusion: The present study indicates that the extract of Coccinia indica exhibits lipid lowering, maintaining lipoproteins concentration and also improves the activities of lipid metabolizing enzyme in hyperglycemic rats leading to an increase in peripheral glucose consumption.https://www.nepjol.info/index.php/AJMS/article/view/24180coccinia indicaserum lipidslipoproteinshmg coa reductaselcat |
| spellingShingle | Mamata Pochhi Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats Asian Journal of Medical Sciences coccinia indica serum lipids lipoproteins hmg coa reductase lcat |
| title | Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats |
| title_full | Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats |
| title_fullStr | Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats |
| title_full_unstemmed | Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats |
| title_short | Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats |
| title_sort | evaluation of antidiabetic potential and hypolipidemic activity of coccinia indica leaves in diabetic albino rats |
| topic | coccinia indica serum lipids lipoproteins hmg coa reductase lcat |
| url | https://www.nepjol.info/index.php/AJMS/article/view/24180 |
| work_keys_str_mv | AT mamatapochhi evaluationofantidiabeticpotentialandhypolipidemicactivityofcocciniaindicaleavesindiabeticalbinorats |