Aberrant angiogenesis: The gateway to diabetic complications
Diabetes Mellitus is a metabolic cum vascular syndrome with resultant abnormalities in both micro- and macrovasculature. The adverse long-term effects of diabetes mellitus have been described to involve many organ systems. Apart from hyperglycemia, abnormalities of angiogenesis may cause or contribu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=918;epage=930;aulast=Kota |
| _version_ | 1811268641269743616 |
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| author | Sunil K Kota Lalit K Meher Sruti Jammula Siva K Kota S. V. S. Krishna Kirtikumar D Modi |
| author_facet | Sunil K Kota Lalit K Meher Sruti Jammula Siva K Kota S. V. S. Krishna Kirtikumar D Modi |
| author_sort | Sunil K Kota |
| collection | DOAJ |
| description | Diabetes Mellitus is a metabolic cum vascular syndrome with resultant abnormalities in both micro- and macrovasculature. The adverse long-term effects of diabetes mellitus have been described to involve many organ systems. Apart from hyperglycemia, abnormalities of angiogenesis may cause or contribute toward many of the clinical manifestations of diabetes. These are implicated in the pathogenesis of vascular abnormalities of the retina, kidneys, and fetus, impaired wound healing, increased risk of rejection of transplanted organs, and impaired formation of coronary collaterals. A perplexing feature of the aberrant angiogenesis is that excessive and insufficient angiogenesis can occur in different organs in the same individual. The current article hereby reviews the molecular mechanisms including abnormalities in growth factors, cytokines, and metabolic derangements, clinical implications, and therapeutic options of dealing with abnormal angiogenesis in diabetes. |
| first_indexed | 2024-04-12T21:26:33Z |
| format | Article |
| id | doaj.art-2c4a6e9d0182493fa24a1b4619bdcd70 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-04-12T21:26:33Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-2c4a6e9d0182493fa24a1b4619bdcd702022-12-22T03:16:10ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002012-01-0116691893010.4103/2230-8210.102992Aberrant angiogenesis: The gateway to diabetic complicationsSunil K KotaLalit K MeherSruti JammulaSiva K KotaS. V. S. KrishnaKirtikumar D ModiDiabetes Mellitus is a metabolic cum vascular syndrome with resultant abnormalities in both micro- and macrovasculature. The adverse long-term effects of diabetes mellitus have been described to involve many organ systems. Apart from hyperglycemia, abnormalities of angiogenesis may cause or contribute toward many of the clinical manifestations of diabetes. These are implicated in the pathogenesis of vascular abnormalities of the retina, kidneys, and fetus, impaired wound healing, increased risk of rejection of transplanted organs, and impaired formation of coronary collaterals. A perplexing feature of the aberrant angiogenesis is that excessive and insufficient angiogenesis can occur in different organs in the same individual. The current article hereby reviews the molecular mechanisms including abnormalities in growth factors, cytokines, and metabolic derangements, clinical implications, and therapeutic options of dealing with abnormal angiogenesis in diabetes.http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=918;epage=930;aulast=KotaAngiogenesisdiabetes mellitusgrowth factorneovascularizationvascular endothelial cell |
| spellingShingle | Sunil K Kota Lalit K Meher Sruti Jammula Siva K Kota S. V. S. Krishna Kirtikumar D Modi Aberrant angiogenesis: The gateway to diabetic complications Indian Journal of Endocrinology and Metabolism Angiogenesis diabetes mellitus growth factor neovascularization vascular endothelial cell |
| title | Aberrant angiogenesis: The gateway to diabetic complications |
| title_full | Aberrant angiogenesis: The gateway to diabetic complications |
| title_fullStr | Aberrant angiogenesis: The gateway to diabetic complications |
| title_full_unstemmed | Aberrant angiogenesis: The gateway to diabetic complications |
| title_short | Aberrant angiogenesis: The gateway to diabetic complications |
| title_sort | aberrant angiogenesis the gateway to diabetic complications |
| topic | Angiogenesis diabetes mellitus growth factor neovascularization vascular endothelial cell |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=918;epage=930;aulast=Kota |
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