Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry
The objective of the current study involved assessment of correlation between the expression of oestrogen receptor (ERα) and Ki-67 by immunohistochemistry, in the genital borne neoplasms in 12 postpubertal bitches between 2 to 12 years of age, presented at University Veterinary Hospitals, Kokkala...
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Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2022-12-01
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| Series: | Journal of Veterinary and Animal Sciences |
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| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_rny8pn.pdf?t=rny8pn |
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| author | Kodange Omkar Tukaram Shibu Simon K. Magnus Paul C. Jayakumar I. S. Sajitha T. Vanesa John |
| author_facet | Kodange Omkar Tukaram Shibu Simon K. Magnus Paul C. Jayakumar I. S. Sajitha T. Vanesa John |
| author_sort | Kodange Omkar Tukaram |
| collection | DOAJ |
| description | The objective of the current study involved assessment of correlation between the
expression of oestrogen receptor (ERα) and Ki-67 by immunohistochemistry, in the genital borne
neoplasms in 12 postpubertal bitches between 2 to 12 years of age, presented at University
Veterinary Hospitals, Kokkalai and Mannuthy. The age group of 5-8 years had the highest
incidence of neoplasia (50.00 %) in comparison with other groups. Episiotomy was performed
for extraluminal tumours while local excision performed in all intraluminal tumours except canine
transmissible venereal tumour (CTVT). A chemotherapeutic regimen involving intravenous infusion
of vincristine sulphate at 0.025 mg/kg was administered to bitches with CTVT and squamous cell
carcinoma (SCC) until complete remission of the neoplasm. The tumours were histopathologically
confirmed as myofibroma (n=6), CTVT (n= 3), leiomyoma (n = 1), SCC (n = 1) and fibroma (n =
1). Immunohistochemical staining of the neoplastic tissues was performed to evaluate ERα and
Ki-67 expression status which could aid in estimating the malignancy potential and influence of
ERα on the same. Spearman’s rank correlation between the immunohistochemical scores for the
expression of ERα and Ki-67 in these tumours was highly significant (p<0.01). The correlation
between ERα and Ki-67 had a significant negative correlation (p < 0.05). In conclusion, the study
suggests that higher expression of Ki-67 of a neoplasm coupled with lower expression of ERα
bears evidence to a malignant process. |
| first_indexed | 2024-04-10T21:20:24Z |
| format | Article |
| id | doaj.art-2c4cfb77434043d4ae8fabf8149e715e |
| institution | Directory Open Access Journal |
| issn | 0971-0701 2582-0605 |
| language | English |
| last_indexed | 2024-04-10T21:20:24Z |
| publishDate | 2022-12-01 |
| publisher | Director of Academics and Research, Kerala Veterinary and Animal Sciences University |
| record_format | Article |
| series | Journal of Veterinary and Animal Sciences |
| spelling | doaj.art-2c4cfb77434043d4ae8fabf8149e715e2023-01-20T04:44:02ZengDirector of Academics and Research, Kerala Veterinary and Animal Sciences UniversityJournal of Veterinary and Animal Sciences0971-07012582-06052022-12-0153460961610.51966/jvas.2022.53.4.609-616Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistryKodange Omkar Tukaram0Shibu Simon1https://orcid.org/0000-0002-4528-548XK. Magnus Paul2https://orcid.org/0000-0003-4727-0828C. Jayakumar3https://orcid.org/0000-0002-8142-4096I. S. Sajitha4https://orcid.org/0000-0002-0315-6081T. Vanesa John 5M.V.Sc. Scholar, Department of Animal Reproduction, Gynaecology and Obstetrics College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651. Kerala Veterinary and Animal Sciences University, Kerala, India.Associate Professor, Department of Animal Reproduction, Gynaecology and Obstetrics College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651. Kerala Veterinary and Animal Sciences University, Kerala, India.Assistant Professor, Department of Animal Reproduction, Gynaecology and Obstetrics College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651. Kerala Veterinary and Animal Sciences University, Kerala, India.Associate Professor and Head, Department of Animal Reproduction, Gynaecology and Obstetrics College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651. Kerala Veterinary and Animal Sciences University, Kerala, India.Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651. Kerala Veterinary and Animal Sciences University, Kerala, India.Assistant Professor, Department of Pathology, JMMCRI, ThrissurThe objective of the current study involved assessment of correlation between the expression of oestrogen receptor (ERα) and Ki-67 by immunohistochemistry, in the genital borne neoplasms in 12 postpubertal bitches between 2 to 12 years of age, presented at University Veterinary Hospitals, Kokkalai and Mannuthy. The age group of 5-8 years had the highest incidence of neoplasia (50.00 %) in comparison with other groups. Episiotomy was performed for extraluminal tumours while local excision performed in all intraluminal tumours except canine transmissible venereal tumour (CTVT). A chemotherapeutic regimen involving intravenous infusion of vincristine sulphate at 0.025 mg/kg was administered to bitches with CTVT and squamous cell carcinoma (SCC) until complete remission of the neoplasm. The tumours were histopathologically confirmed as myofibroma (n=6), CTVT (n= 3), leiomyoma (n = 1), SCC (n = 1) and fibroma (n = 1). Immunohistochemical staining of the neoplastic tissues was performed to evaluate ERα and Ki-67 expression status which could aid in estimating the malignancy potential and influence of ERα on the same. Spearman’s rank correlation between the immunohistochemical scores for the expression of ERα and Ki-67 in these tumours was highly significant (p<0.01). The correlation between ERα and Ki-67 had a significant negative correlation (p < 0.05). In conclusion, the study suggests that higher expression of Ki-67 of a neoplasm coupled with lower expression of ERα bears evidence to a malignant process.https://jvas.in/public_html/upload/article_file/article_file_rny8pn.pdf?t=rny8pncaninegenital neoplasmsimmunohistochemistryerαki-67 |
| spellingShingle | Kodange Omkar Tukaram Shibu Simon K. Magnus Paul C. Jayakumar I. S. Sajitha T. Vanesa John Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry Journal of Veterinary and Animal Sciences canine genital neoplasms immunohistochemistry erα ki-67 |
| title | Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry |
| title_full | Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry |
| title_fullStr | Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry |
| title_full_unstemmed | Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry |
| title_short | Correlation between oestrogen receptor (ERα) and Ki-67 receptor expression in canine genital neoplasms by immunohistochemistry |
| title_sort | correlation between oestrogen receptor erα and ki 67 receptor expression in canine genital neoplasms by immunohistochemistry |
| topic | canine genital neoplasms immunohistochemistry erα ki-67 |
| url | https://jvas.in/public_html/upload/article_file/article_file_rny8pn.pdf?t=rny8pn |
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