Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota
Feline chronic gingivostomatitis (FCGS) has an unclear pathogenesis with the oral microbiome and viral infections, such as feline immunodeficiency virus (FIV), thought to contribute. Although the relationship between the FIV status and FCGS is not clear, one theory is FIV-induced immune dysregulatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/5/383 |
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| author | Caitlin E. Older Márcia de Oliveira Sampaio Gomes Aline Rodrigues Hoffmann Mariel Dalmédico Policano Camila Aparecida Cruz dos Reis Adriano Bonfim Carregaro Carlos Eduardo Ambrósio Valéria Maria Lara Carregaro |
| author_facet | Caitlin E. Older Márcia de Oliveira Sampaio Gomes Aline Rodrigues Hoffmann Mariel Dalmédico Policano Camila Aparecida Cruz dos Reis Adriano Bonfim Carregaro Carlos Eduardo Ambrósio Valéria Maria Lara Carregaro |
| author_sort | Caitlin E. Older |
| collection | DOAJ |
| description | Feline chronic gingivostomatitis (FCGS) has an unclear pathogenesis with the oral microbiome and viral infections, such as feline immunodeficiency virus (FIV), thought to contribute. Although the relationship between the FIV status and FCGS is not clear, one theory is FIV-induced immune dysregulation could contribute to oral dysbiosis, promoting FCGS development. To further understand the relationship between FCGS, FIV infection, and the oral microbiome, oral cavities of forty cats fitting within 4 groups (FIV- without gingivitis, FIV+ without gingivitis, FIV- with gingivitis, FIV+ with gingivitis) were swabbed. Next generation sequencing targeting the V4 region of the 16s rRNA gene was performed for bacterial community profiling. No differences in diversity were observed, however, analysis of the data in terms of gingivitis revealed differences in the relative abundance of taxa and predicted functional output. <i>Odoribacter</i> spp., a bacteria associated with oral disease, was found in higher relative abundances in cats with the highest gingivitis grade. Cats with gingivitis were also found to harbor communities more involved in production of short-chain fatty acids, which have been connected with oral disease. Significant findings associated with the FIV status were few and of low impact, suggesting any connection between the FIV status and FCGS is likely not related to the oral microbiota. |
| first_indexed | 2024-03-10T19:46:27Z |
| format | Article |
| id | doaj.art-2c4d4f093cc04d2591f75d36955cf668 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T19:46:27Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-2c4d4f093cc04d2591f75d36955cf6682023-11-20T00:43:57ZengMDPI AGPathogens2076-08172020-05-019538310.3390/pathogens9050383Influence of the FIV Status and Chronic Gingivitis on Feline Oral MicrobiotaCaitlin E. Older0Márcia de Oliveira Sampaio Gomes1Aline Rodrigues Hoffmann2Mariel Dalmédico Policano3Camila Aparecida Cruz dos Reis4Adriano Bonfim Carregaro5Carlos Eduardo Ambrósio6Valéria Maria Lara Carregaro7Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843, USAInternal Medicine Department, College of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, BrazilDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843, USADepartment of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga 13635-900, BrazilDepartment of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga 13635-900, BrazilDepartment of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga 13635-900, BrazilDepartment of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga 13635-900, BrazilDepartment of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga 13635-900, BrazilFeline chronic gingivostomatitis (FCGS) has an unclear pathogenesis with the oral microbiome and viral infections, such as feline immunodeficiency virus (FIV), thought to contribute. Although the relationship between the FIV status and FCGS is not clear, one theory is FIV-induced immune dysregulation could contribute to oral dysbiosis, promoting FCGS development. To further understand the relationship between FCGS, FIV infection, and the oral microbiome, oral cavities of forty cats fitting within 4 groups (FIV- without gingivitis, FIV+ without gingivitis, FIV- with gingivitis, FIV+ with gingivitis) were swabbed. Next generation sequencing targeting the V4 region of the 16s rRNA gene was performed for bacterial community profiling. No differences in diversity were observed, however, analysis of the data in terms of gingivitis revealed differences in the relative abundance of taxa and predicted functional output. <i>Odoribacter</i> spp., a bacteria associated with oral disease, was found in higher relative abundances in cats with the highest gingivitis grade. Cats with gingivitis were also found to harbor communities more involved in production of short-chain fatty acids, which have been connected with oral disease. Significant findings associated with the FIV status were few and of low impact, suggesting any connection between the FIV status and FCGS is likely not related to the oral microbiota.https://www.mdpi.com/2076-0817/9/5/383microbiotafelinegingivostomatitisoral diseasegingivitisFIV |
| spellingShingle | Caitlin E. Older Márcia de Oliveira Sampaio Gomes Aline Rodrigues Hoffmann Mariel Dalmédico Policano Camila Aparecida Cruz dos Reis Adriano Bonfim Carregaro Carlos Eduardo Ambrósio Valéria Maria Lara Carregaro Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota Pathogens microbiota feline gingivostomatitis oral disease gingivitis FIV |
| title | Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota |
| title_full | Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota |
| title_fullStr | Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota |
| title_full_unstemmed | Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota |
| title_short | Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota |
| title_sort | influence of the fiv status and chronic gingivitis on feline oral microbiota |
| topic | microbiota feline gingivostomatitis oral disease gingivitis FIV |
| url | https://www.mdpi.com/2076-0817/9/5/383 |
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