6-Bromoindirubin-3’-oxime promotes osteogenic differentiation of canine BMSCs through inhibition of GSK3β activity and activation of the Wnt/β-catenin signaling pathway

6-Bromoindirubin-3’-oxime promotes osteogenic differentiation of canine BMSCs through inhibition of GSK3β activity and activation of the Wnt/β-catenin signaling pathway

This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs a...

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Bibliographic Details
Main Authors: XIAO-E ZHAO, ZHENSHAN YANG, ZHEN GAO, JUNBANG GE, QIANG WEI, BAOHUA MA
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2019-03-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
Bone mesenchymal stem cells
bromoindirubin oxime
osteogenetic differentiation
canine
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100610&lng=en&tlng=en

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